Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013333)
Formula Reactant Morphine Product Morphine-3-glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
UDP-glucuronosyltransferase 2B4 (UGT2B4) DME Info
UDP-glucuronosyltransferase 2B15 (UGT2B15) DME Info
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
UDP-glucuronosyltransferase 1A10 (UGT1A10) DME Info
UDP-glucuronosyltransferase 2B17 (UGT2B17) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004807 Morphine Codeine Conjugation - Methylationn Morphine [1]
MR004808 Morphine Morphine ethereal sulfate Conjugation - Sulfation Morphine [1]
MR004804 Morphine Morphine glucuronide Conjugation - Glucuronidation Morphine [2], [3], [4]
MR004806 Morphine Normorphine Oxidation - Demethylation Morphine [1]
MR004097 Morphine Morphine 3 glucuronide Conjugation - Glucuronidation Codeine [5]
MR004098 Morphine Morphine 6 glucuronide Unclear Codeine [5]
MR012875 Morphine Morphine-6-glucuronide Unclear Ethylmorphine [6]
MR004099 Morphine Normorphine Conjugation - Glucuronidation Codeine [7]
MR012869 Morphine Normorphine Unclear Ethylmorphine [8]
MR013335 Morphine Codeine Conjugation - Methylationn Heroin [1]
MR013336 Morphine Morphine ethereal sulfate Conjugation - Sulfation Heroin [1]
MR013332 Morphine Morphine-6-glucuronide Conjugation - Glucuronidation Heroin [9]
MR013334 Morphine Normorphine Oxidation - Demethylation Heroin [1]
References
1 Morphine: pharmacokinetics and clinical practice
2 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
3 Metabolism and pharmacokinetics of morphine in neonates: A review
4 Morphine metabolism, transport and brain disposition
5 DrugBank(Pharmacology-Metabolism):Codeine
6 Aniline and its metabolites generate free radicals in yeast
7 Diclofenac does not interact with codeine metabolism in vivo: a study in healthy volunteers
8 Biotransformation and pharmacokinetics of ethylmorphine after a single oral dose. Br J Clin Pharmacol. 1995 Jun;39(6):611-20.
9 PharmGKB:Heroin

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