Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013352)
Formula Reactant Quinone methide Product O-demethylated tetrandrine GSH conjugate
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A5 (CYP3A5) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006292 Eugenol Quinone methide Unclear Eugenol [1]
MR013351 O-demethylated tetrandrine Quinone methide Unclear CBT-1 [2]
References
1 Applying sputum as a diagnostic tool in pneumonia: limited yield, minimal impact on treatment decisions
2 CYP3A5 mediates bioactivation and cytotoxicity of tetrandrine. Arch Toxicol. 2016 Jul;90(7):1737-48.

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