Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013409)
Formula
SVG example
Hydrolysis
Reactant Dabigatran etexilate Product BIBR0951/M2
Reactant Info Product Info
Metabolic Enzyme Carboxylesterase 2 (CES2) DME Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013428 Dabigatran etexilate BIBR1087/M1 Hydrolysis - Hydrolysis Dabigatran etexilate [1], [2], [3]
MR013432 Dabigatran etexilate Dabigatran Hydrolysis - Hydrolysis Dabigatran etexilate [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013410 BIBR0951/M2 Dabigatran Hydrolysis - Hydrolysis Dabigatran etexilate [2]
References
1 The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans
2 Conventional liquid chromatography/triple quadrupole mass spectrometry based metabolite identification and semi-quantitative estimation approach in the investigation of in vitro dabigatran etexilate metabolism. Anal Bioanal Chem. 2013 Feb;405(5):1695-704.
3 Identification of carboxylesterase-dependent dabigatran etexilate hydrolysis
4 DrugBank(Pharmacology-Metabolism): Dabigatran etexilate

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