Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013410)
Formula
CES1 ...
SVG example
Hydrolysis
Reactant BIBR0951/M2 Product Dabigatran
Reactant Info Product Info
Metabolic Enzyme Carboxylesterase 1 (CES1) DME Info
Carboxylesterase 2 (CES2) DME Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013409 Dabigatran etexilate BIBR0951/M2 Hydrolysis - Hydrolysis Dabigatran etexilate [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013432 Dabigatran etexilate Dabigatran Hydrolysis - Hydrolysis Dabigatran etexilate [3]
References
1 The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans
2 Conventional liquid chromatography/triple quadrupole mass spectrometry based metabolite identification and semi-quantitative estimation approach in the investigation of in vitro dabigatran etexilate metabolism. Anal Bioanal Chem. 2013 Feb;405(5):1695-704.
3 DrugBank(Pharmacology-Metabolism): Dabigatran etexilate

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