Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013528)
Formula
SVG example
N-Dealkylation
Reactant N-ethylnorephedrine Product Norephedrine
Reactant Info Product Info
Metabolic Enzyme DME Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013530 N-diethylnorephedrine N-ethylnorephedrine Oxidation - N-Dealkylation Amfepramone [1]
MR013527 N-ethylaminopropiophenone N-ethylnorephedrine Oxidation - N-Dealkylation Amfepramone [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000222 Amphetamine Norephedrine Oxidation - Hydroxylation Amphetamine [2]
MR009987 Amphetamine Norephedrine Unclear - Unclear Metamfetamine [3]
MR010003 Amphetamine Norephedrine Unclear - Unclear Methamphetamine hydrochloride [3]
MR006888 D-amphetamine Norephedrine Oxidation - Oxidationn Lisdexamfetamine [4]
MR013526 Cathinone Norephedrine Reduction - Carbonyl-reduction Amfepramone [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006889 Norephedrine (-)-4-Hydroxynorephedrin Oxidation - Oxidationn Lisdexamfetamine [4]
MR009988 Norephedrine 4-Hydroxynorephedrine Unclear - Unclear Metamfetamine [3]
MR010004 Norephedrine 4-Hydroxynorephedrine Unclear - Unclear Methamphetamine hydrochloride [3]
References
1 Re-evaluation of the metabolism and excretion of diethylpropion in non-sustained and sustained release formulations
2 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
3 Metabolism of ( 14 C)methamphetamine in man, the guinea pig and the rat
4 Preclinical pharmacokinetics, pharmacology and toxicology of lisdexamfetamine: a novel d-amphetamine pro-drug. Neuropharmacology. 2014 Dec;87:41-50.

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