Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000222)
Formula
SVG example
Hydroxylation
Reactant Amphetamine Product Norephedrine
Reactant Info Product Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000220 Amphetamine 4-hydroxyamphetamine Oxidation - Hydroxylation Amphetamine [1]
MR000221 Amphetamine Phenylacetone Oxidation - Oxidative Deamination Amphetamine [1]
MR009989 Amphetamine 4-Hydroxyamphetamine Unclear - Unclear Metamfetamine [2]
MR010005 Amphetamine 4-Hydroxyamphetamine Unclear - Unclear Methamphetamine hydrochloride [2]
MR009985 Amphetamine Metamfetamine Metabolite M5 Unclear - Unclear Metamfetamine [2]
MR010001 Amphetamine Metamfetamine Metabolite M5 Unclear - Unclear Methamphetamine hydrochloride [2]
MR007172 Amphetamine Norephedrine Norpxudoephed rine Oxidation - eta-hydroxylation Famprofazone [3]
MR007171 Amphetamine p-Hydroxyamphetamine Oxidation - p-hydroxylation Famprofazone [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006888 D-amphetamine Norephedrine Oxidation - Oxidationn Lisdexamfetamine [4]
MR013526 Cathinone Norephedrine Reduction - Carbonyl-reduction Amfepramone [5]
MR013528 N-ethylnorephedrine Norephedrine Oxidation - N-Dealkylation Amfepramone [5]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006889 Norephedrine (-)-4-Hydroxynorephedrin Oxidation - Oxidationn Lisdexamfetamine [4]
MR009988 Norephedrine 4-Hydroxynorephedrine Unclear - Unclear Metamfetamine [2]
MR010004 Norephedrine 4-Hydroxynorephedrine Unclear - Unclear Methamphetamine hydrochloride [2]
References
1 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
2 Metabolism of ( 14 C)methamphetamine in man, the guinea pig and the rat
3 Identification of new urinary metabolites of famprofazone in humans
4 Preclinical pharmacokinetics, pharmacology and toxicology of lisdexamfetamine: a novel d-amphetamine pro-drug. Neuropharmacology. 2014 Dec;87:41-50.
5 Re-evaluation of the metabolism and excretion of diethylpropion in non-sustained and sustained release formulations

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