Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013595)
Formula
SVG example
Deacetylation
Reactant Diacerein Product Rhein
Reactant Info Product Info
Metabolic Type Oxidation - Deacetylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013604 Diacerein Rhein Metabolite M28 Conjugation - Glucuronidation Diacerein [1]
MR013605 Diacerein Rhein Metabolite M5 Conjugation - Glucuronidation Diacerein [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007444 8-glucosyl-rheinanthrone Rhein Unclear DB-041901 [2]
MR007442 Rheinanthrone Rhein Oxidation - Oxidationn DB-041901 [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013596 Rhein Aloe-emodin Reduction - Reduction Diacerein [1]
MR013601 Rhein Rhein glucuronide Unclear Diacerein [1]
MR013603 Rhein Rhein Metabolite M10 Multi-steps Reaction - Glucuronidation; hydroxylation Diacerein [1]
MR013599 Rhein Rhein Metabolite M13 Conjugation - Cglucuronidation Diacerein [1]
MR013602 Rhein Rhein sulfate Unclear Diacerein [1]
References
1 Rapid characterization of the potential active metabolites of diacerein in rat plasma based on UHPLC-Q-exactive orbitrap mass spectrometry and molecular docking
2 Metabolism of sennosides by human intestinal bacteria
3 Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb extract

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