Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013603)
Formula Reactant Rhein Product Rhein Metabolite M10
Reactant Info Product Info
Metabolic Type Multi-steps Reaction - Glucuronidation; hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013595 Diacerein Rhein Oxidation - Deacetylation Diacerein [1], [2]
MR007444 8-glucosyl-rheinanthrone Rhein Unclear DB-041901 [3]
MR007442 Rheinanthrone Rhein Oxidation - Oxidationn DB-041901 [4]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013596 Rhein Aloe-emodin Reduction - Reduction Diacerein [1]
MR013601 Rhein Rhein glucuronide Unclear Diacerein [1]
MR013599 Rhein Rhein Metabolite M13 Conjugation - Cglucuronidation Diacerein [1]
MR013602 Rhein Rhein sulfate Unclear Diacerein [1]
References
1 Rapid characterization of the potential active metabolites of diacerein in rat plasma based on UHPLC-Q-exactive orbitrap mass spectrometry and molecular docking
2 Clinical pharmacokinetics of diacerein
3 Metabolism of sennosides by human intestinal bacteria
4 Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb extract

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