Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013643)
Formula
CYP2C19 ...
SVG example
Oxidative Defluorination; Glucuronide conjugation
Reactant PT2385 M7 Product PT2385 M12
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
UDP-glucuronosyltransferase 2B4 (UGT2B4) DME Info
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
UDP-glucuronosyltransferase 2B15 (UGT2B15) DME Info
UDP-glucuronosyltransferase 2B17 (UGT2B17) DME Info
Metabolic Type Multi-steps Reaction - Oxidative Defluorination; Glucuronide conjugation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013642 PT2385 PT2385 M7 Oxidation - Oxidative Defluorination PT2385 [1]
References
1 Metabolic Profiling of the Novel Hypoxia-Inducible Factor 2 Inhibitor PT2385 In Vivo and In Vitro

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