Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013664)
Formula Reactant GS-56650 Product GS-606965
Reactant Info Product Info
Metabolic Enzyme Adenosine 5'-monophosphoramidase (HINT1) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013663 Sofosbuvir GS-56650 Unclear Sofosbuvir [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013665 GS-606965 GS-461203 Unclear Sofosbuvir [1], [2]
References
1 Pharmacokinetics, safety, and tolerability of GS-9851, a nucleotide analog polymerase inhibitor for hepatitis C virus, following single ascending doses in healthy subjects
2 Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. J Biol Chem. 2010 Nov 5;285(45):34337-47.

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