Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013682)
Formula
SVG example
Demethylation
Reactant Enzalutamide metabolite M6 enzalutamide Product N-desmethyl enzalutamide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013681 Enzalutamide Enzalutamide metabolite M6 enzalutamide Oxidation - Hydroxylation Enzalutamide [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013683 N-desmethyl enzalutamide Carboxyl metabolite enzalutamide (M1) Unclear Enzalutamide [3], [1]
References
1 Pharmacokinetic Aspects of the Two Novel Oral Drugs Used for Metastatic Castration-Resistant Prostate Cancer: Abiraterone Acetate and Enzalutamide
2 Clinical Pharmacokinetic Studies of Enzalutamide
3 Absorption, Distribution, Metabolism, and Excretion of the Androgen Receptor Inhibitor Enzalutamide in Rats and Dogs

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