Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013683)
Formula Reactant N-desmethyl enzalutamide Product Carboxyl metabolite enzalutamide (M1)
Reactant Info Product Info
Metabolic Enzyme Carboxylesterase 1 (CES1) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013682 Enzalutamide metabolite M6 enzalutamide N-desmethyl enzalutamide Oxidation - Demethylation Enzalutamide [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013689 Indocyanine green Carboxyl metabolite enzalutamide (M1) Multi-steps Reaction - Amide Hydrolysis; Demethylation Enzalutamide [1], [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013690 Carboxyl metabolite enzalutamide (M1) Enzalutamide metabolite M5 Unclear Enzalutamide [1]
MR013684 Carboxyl metabolite enzalutamide (M1) Enzalutamide metabolite M11 Conjugation - Acyl glucuronide conjugation Enzalutamide [1]
References
1 Absorption, Distribution, Metabolism, and Excretion of the Androgen Receptor Inhibitor Enzalutamide in Rats and Dogs
2 Pharmacokinetic Aspects of the Two Novel Oral Drugs Used for Metastatic Castration-Resistant Prostate Cancer: Abiraterone Acetate and Enzalutamide

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