Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013716)
Formula
CYP2D6 ...
SVG example
Reactant PF-00734200 Product PF-00734200 metabolite M5
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013726 PF-00734200 PF-00734200 metabolite M1 Unclear PF-00734200 [1]
MR013727 PF-00734200 PF-00734200 metabolite M10 Unclear PF-00734200 [1]
MR013719 PF-00734200 PF-00734200 metabolite M11 Unclear PF-00734200 [1]
MR013729 PF-00734200 PF-00734200 metabolite M12 Unclear PF-00734200 [1]
MR013722 PF-00734200 PF-00734200 metabolite M13 Unclear PF-00734200 [1]
MR013730 PF-00734200 PF-00734200 metabolite M14 Unclear PF-00734200 [1]
MR013723 PF-00734200 PF-00734200 metabolite M15 Conjugation - Glucosidation PF-00734200 [1]
MR013734 PF-00734200 PF-00734200 metabolite M17 Unclear PF-00734200 [1]
MR013724 PF-00734200 PF-00734200 metabolite M18 Unclear PF-00734200 [1]
MR013725 PF-00734200 PF-00734200 metabolite M2 Hydrolysis - Amide hydrolysis PF-00734200 [1]
MR013728 PF-00734200 PF-00734200 metabolite M3 Oxidation - N-dealkylation PF-00734200 [1]
MR013731 PF-00734200 PF-00734200 metabolite M7 Unclear PF-00734200 [1]
MR013733 PF-00734200 PF-00734200 metabolite M8 Unclear PF-00734200 [1]
MR013732 PF-00734200 PF-00734200 metabolite M9 Conjugation - Carbamoyl glucuronidation PF-00734200 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013717 PF-00734200 metabolite M5 PF-00734200 metabolite M4 Unclear PF-00734200 [1]
MR013718 PF-00734200 metabolite M5 PF-00734200 metabolite M6 Unclear PF-00734200 [1]
References
1 Metabolism, excretion, and pharmacokinetics of ((3,3-difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a dipeptidyl peptidase inhibitor, in rat, dog and human

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