Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013728)
Formula
SVG example
N-dealkylation
Reactant PF-00734200 Product PF-00734200 metabolite M3
Reactant Info Product Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013726 PF-00734200 PF-00734200 metabolite M1 Unclear PF-00734200 [1]
MR013727 PF-00734200 PF-00734200 metabolite M10 Unclear PF-00734200 [1]
MR013719 PF-00734200 PF-00734200 metabolite M11 Unclear PF-00734200 [1]
MR013729 PF-00734200 PF-00734200 metabolite M12 Unclear PF-00734200 [1]
MR013722 PF-00734200 PF-00734200 metabolite M13 Unclear PF-00734200 [1]
MR013730 PF-00734200 PF-00734200 metabolite M14 Unclear PF-00734200 [1]
MR013723 PF-00734200 PF-00734200 metabolite M15 Conjugation - Glucosidation PF-00734200 [1]
MR013734 PF-00734200 PF-00734200 metabolite M17 Unclear PF-00734200 [1]
MR013724 PF-00734200 PF-00734200 metabolite M18 Unclear PF-00734200 [1]
MR013725 PF-00734200 PF-00734200 metabolite M2 Hydrolysis - Amide hydrolysis PF-00734200 [1]
MR013716 PF-00734200 PF-00734200 metabolite M5 Unclear PF-00734200 [1]
MR013731 PF-00734200 PF-00734200 metabolite M7 Unclear PF-00734200 [1]
MR013733 PF-00734200 PF-00734200 metabolite M8 Unclear PF-00734200 [1]
MR013732 PF-00734200 PF-00734200 metabolite M9 Conjugation - Carbamoyl glucuronidation PF-00734200 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000523 Buspirone 1-Pyrimidinylpiperazine Oxidation - N-Dealkylation Buspirone [2], [3], [4]
MR012622 Gepirone 2-(1-Piperazinyl)pyrimidine Unclear - Unclear Gepirone [5]
MR001842 Org-33062 1-Pyrimidinylpiperazine Unclear Org-33062 [6]
MR008816 Tandospirone 1\(2\pyrimidinyl)\piperazine (1\PP) Oxidation - Oxidative cleavage Tandospirone [7], [8]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012623 2-(1-Piperazinyl)pyrimidine 2-(Piperazin-1-yl)pyrimidin-5-ol Unclear - Unclear Gepirone [9]
MR008817 1\(2\pyrimidinyl)\piperazine (1\PP) 5-OH-1-PP Unclear - Unclear Tandospirone [8]
References
1 Metabolism, excretion, and pharmacokinetics of ((3,3-difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a dipeptidyl peptidase inhibitor, in rat, dog and human
2 Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes. Drug Metab Dispos. 2005 Apr;33(4):500-7.
3 DrugBank(Pharmacology-Metabolism)Buspirone
4 Interaction of buspirone and its major metabolites with human organic cation transporters. Fundam Clin Pharmacol. 2023 Feb 26. doi: 10.1111/fcp.12883.
5 Gepirone and 1-(2-pyrimidinyl)-piperazine in vitro: human cytochromes mediating transformation and cytochrome inhibitory effects
6 Human cytochromes mediating gepirone biotransformation at low substrate concentrations. Biopharm Drug Dispos. 2003 Mar;24(2):87-94.
7 Simultaneous determination of tandospirone and its active metabolite, 1-[2-pyrimidyl]-piperazine in rat plasma by LC-MS/MS and its application to a pharmacokinetic study
8 Identification of CYP3A4 as the primary cytochrome P450 responsible for the metabolism of tandospirone by human liver microsomes
9 PubChem:Gepirone

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