Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013779)
Formula
CYP2D6 ...
SVG example
Demethylenation
Reactant Berberine Product Demethyleneberberine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2E1 (CYP2E1) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - Demethylenation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013795 Berberine 3,9-demethylpalmatine Unclear - Unclear Berberine [1]
MR013787 Berberine Berberrubine Oxidation - Demethylation Berberine [1], [2], [3]
MR013792 Berberine Columbamine Reduction - Reduction Berberine [1]
MR013796 Berberine Dihydroberberine Reduction - Reduction Berberine [1]
MR013774 Berberine Jatrorrhizine Reduction - Reduction Berberine [1]
MR013789 Berberine Thalfendine Oxidation - Demethylation Berberine [1], [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013780 Demethyleneberberine 2,3,10-trihydroxyberberine Oxidation - Demethylation Berberine [1], [2]
MR013782 Demethyleneberberine 2,3,9-trihydroxyberberine Unclear - Unclear Berberine [1]
MR013783 Demethyleneberberine Demethyleneberberine-2,3-di-O-beta-D-glucuronide Conjugation - Glucuronidation Berberine [1]
MR013781 Demethyleneberberine Demethyleneberberine-2-O-sulfate Conjugation - Sulfation Berberine [1]
References
1 The metabolism of berberine and its contribution to the pharmacological effects
2 CYP2D plays a major role in berberine metabolism in liver of mice and humans
3 Transformation of berberine to its demethylated metabolites by the CYP51 enzyme in the gut microbiota

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