Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013795)
Formula Reactant Berberine Product 3,9-demethylpalmatine
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013787 Berberine Berberrubine Oxidation - Demethylation Berberine [1], [2], [3]
MR013792 Berberine Columbamine Reduction - Reduction Berberine [1]
MR013779 Berberine Demethyleneberberine Oxidation - Demethylenation Berberine [1], [2]
MR013796 Berberine Dihydroberberine Reduction - Reduction Berberine [1]
MR013774 Berberine Jatrorrhizine Reduction - Reduction Berberine [1]
MR013789 Berberine Thalfendine Oxidation - Demethylation Berberine [1], [2], [3]
References
1 The metabolism of berberine and its contribution to the pharmacological effects
2 CYP2D plays a major role in berberine metabolism in liver of mice and humans
3 Transformation of berberine to its demethylated metabolites by the CYP51 enzyme in the gut microbiota

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