Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR014048)
Formula Reactant Remdesivir Nucleoside Monophosphate Product Remdesivir Nucleoside Triphosphate
Reactant Info Product Info
Metabolic Type Conjugation - Phosphorylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009118 GS-441524 GS-441524-MP Unclear - Unclear GS-441524 [1]
MR014047 Remdesivir Alanine Metabolite (Ala-Met; GS-704277) Remdesivir Nucleoside Monophosphate Unclear Remdesivir [2]
MR013219 Remdesivir M1 Remdesivir Nucleoside Monophosphate Unclear Remdesivir [2]
MR013212 Remdesivir Alanine Metabolite (Ala-Met; GS-704277) Remdesivir Nucleoside Monophosphate Oxidation - Deamination Remdesivir [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009119 GS-441524-MP GS-441524-DP Unclear - Unclear GS-441524 [1]
MR014046 Remdesivir Nucleoside Monophosphate GS-441524 Unclear Remdesivir [4]
MR013214 Remdesivir Nucleoside Monophosphate GS-441524 Unclear Remdesivir [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013216 Remdesivir Nucleoside Triphosphate Remdesivir-DP Hydrolysis - Hydrolysis Remdesivir [5]
MR013217 Remdesivir Nucleoside Triphosphate Remdesivir-MP Hydrolysis - Hydrolysis Remdesivir [5]
References
1 Comparison of anti-SARS-CoV-2 activity and intracellular metabolism of remdesivir and its parent nucleoside
2 Viral target and metabolism-based rationale for combined use of recently authorized small molecule COVID-19 medicines: Molnupiravir, nirmatrelvir, and remdesivir
3 Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19
4 Population pharmacokinetic modeling of GS-441524, the active metabolite of remdesivir, in Japanese COVID-19 patients with renal dysfunction
5 Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, and molnupiravir

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