Details of the Metabolic Reaction (MR)
General Information of This Metabolic Reaction (MR) (ID: MR013219) | ||||||
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Formula |
CES1
...
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Reactant | Remdesivir M1 | Product | Remdesivir Nucleoside Monophosphate | |||
Reactant Info | Product Info | |||||
Metabolic Enzyme | Carboxylesterase 1 (CES1) | DME Info | ||||
Cathepsin A (CTSA) | DME Info | |||||
Other MR(s) Related to The Reactant of This MR | |||||||||||||||||||||||||||||
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Other MR(s) That Produce The Reactant of This MR | |||||||||||||||||||||||||||||
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References | ||||||
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1 | Viral target and metabolism-based rationale for combined use of recently authorized small molecule COVID-19 medicines: Molnupiravir, nirmatrelvir, and remdesivir | |||||
2 | Comparison of anti-SARS-CoV-2 activity and intracellular metabolism of remdesivir and its parent nucleoside | |||||
3 | Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19 | |||||
4 | Population pharmacokinetic modeling of GS-441524, the active metabolite of remdesivir, in Japanese COVID-19 patients with renal dysfunction | |||||
5 | Remdesivir: Review of Pharmacology, Pre-clinical Data, and Emerging Clinical Experience for COVID-19 |
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