Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00011)
Xenobiotics Name
Carbamazepine
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
2554
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Steroid 17-alpha-monooxygenase (CYP17A1) DME Info Homo sapiens [1]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [2]
Fatty acid desaturase 2 (FADS2) DME Info Homo sapiens [3]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [4]
Beta-HSD adrenal and gonadal type (HSD3B2) DME Info Homo sapiens [1]
Cytosolic phospholipase A2 (PLA2G4A) DME Info Homo sapiens [5]
Serum paraoxonase/arylesterase 1 (PON1) DME Info Homo sapiens [6]
DME(s) Induced by This Xenobiotics
Microsomal cytochrome MCB5 (CYB5A) DME Info Homo sapiens [7]
Aldosterone synthase (CYP11B2) DME Info Homo sapiens [4]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [7]
Cytochrome P450 2A6 (CYP2A6) DME Info Homo sapiens [7]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [8]
Mephenytoin 4-hydroxylase (CYP2C19) DME Info Homo sapiens [7]
Cytochrome P450 2C8 (CYP2C8) DME Info Homo sapiens [7]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [9]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [10]
Cytochrome P450 3A43 (CYP3A43) DME Info Homo sapiens [7]
Cytochrome P450 3A5 (CYP3A5) DME Info Homo sapiens [11]
Cytochrome P450 3A7 (CYP3A7) DME Info Homo sapiens [7]
Leukotriene B4 omega-hydroxylase (CYP4F3) DME Info Homo sapiens [7]
Glutathione S-transferase alpha-1 (GSTA1) DME Info Homo sapiens [7]
Monoamine oxidase type A (MAO-A) DME Info Homo sapiens [7]
Monoamine oxidase type B (MAO-B) DME Info Homo sapiens [7]
N-acetyltransferase 1 (NAT1) DME Info Homo sapiens [7]
N-acetyltransferase 2 (NAT2) DME Info Homo sapiens [7]
NADPH-cytochrome P450 reductase (CPR) DME Info Homo sapiens [7]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [12]
UDP-glucuronosyltransferase 2B15 (UGT2B15) DME Info Homo sapiens [7]
References
1 Effects of anticonvulsants on human p450c17 (17alpha-hydroxylase/17,20 lyase) and 3beta-hydroxysteroid dehydrogenase type 2. Epilepsia. 2005 Mar;46(3):444-8.
2 Inhibition of tumour spheroid-induced prometastatic intravasation gates in the lymph endothelial cell barrier by carbamazepine: drug testing in a 3D model. Arch Toxicol. 2014 Mar;88(3):691-9.
3 Phospholipidosis induced by PPARgama signaling in human bronchial epithelial (BEAS-2B) cells exposed to amiodarone. Toxicol Sci. 2011 Mar;120(1):98-108.
4 Differential effects of antiepileptic drugs on steroidogenesis in a human in vitro cell model. Acta Neurol Scand Suppl. 2009;(189):14-21.
5 Chronic carbamazepine selectively downregulates cytosolic phospholipase A2 expression and cyclooxygenase activity in rat brain. Biol Psychiatry. 2004 Aug 15;56(4):248-54.
6 Antiepileptic drugs: impacts on human serum paraoxonase-1. J Biochem Mol Toxicol. 2017 Jun;31(6).
7 Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine. Clin Pharmacol Ther. 2006 Nov;80(5):440-456.
8 Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers. Drug Metab Dispos. 2004 Mar;32(3):348-58.
9 Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes. J Biochem Mol Toxicol. 2009 Jan-Feb;23(1):43-58.
10 Generation of proliferating human hepatocytes using Upcyte?technology: characterisation and applications in induction and cytotoxicity assays. Xenobiotica. 2012 Oct;42(10):939-56.
11 Induction of CYP3As in HepG2 cells by several drugs. Association between induction of CYP3A4 and expression of glucocorticoid receptor. Biol Pharm Bull. 2003 Apr;26(4):510-7.
12 Induction of the UDP-glucuronosyltransferase 1A1 during the perinatal period can cause neurodevelopmental toxicity. Mol Pharmacol. 2016 Sep;90(3):265-74.

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