Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00086)
Xenobiotics Name
Troglitazone
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5591"></iframe>
3D MOL 2D MOL
PubChem CID
5591
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Alcohol dehydrogenase class-I gamma (ADH1C) DME Info Homo sapiens [1]
Steroid 17-alpha-monooxygenase (CYP17A1) DME Info Homo sapiens [2]
Cytochrome P450 2J2 (CYP2J2) DME Info Homo sapiens [2]
Cytochrome P450 3A7 (CYP3A7) DME Info Homo sapiens [2]
Thymidylate kinase (DTYMK) DME Info Homo sapiens [3]
Monoamine oxidase type A (MAO-A) DME Info Homo sapiens [2]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [4]
Superoxide dismutase 1 (SOD1) DME Info Homo sapiens [5]
Thymidylate synthase (TYMS) DME Info Homo sapiens [6]
DME(s) Induced by This Xenobiotics
Alanyl aminopeptidase (ANPEP) DME Info Homo sapiens [6]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [7]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [2]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [2]
Mephenytoin 4-hydroxylase (CYP2C19) DME Info Homo sapiens [2]
Cytochrome P450 2C8 (CYP2C8) DME Info Homo sapiens [2]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [7]
Bifunctional epoxide hydrolase 2 (EPHX2) DME Info Homo sapiens [8]
L-glutamine amidohydrolase (GLS) DME Info Homo sapiens [9]
Cellular glutathione peroxidase (GPX1) DME Info Homo sapiens [6]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [10]
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DME Info Homo sapiens [11]
Metallothionein-2A (MT2A) DME Info Homo sapiens [2]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [9]
Nitric oxide synthase endothelial (NOS3) DME Info Homo sapiens [12]
NADPH-cytochrome P450 reductase (CPR) DME Info Homo sapiens [2]
Proline dehydrogenase 1 (PRODH) DME Info Homo sapiens [11]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [2]
References
1 Negative regulation of superoxide dismutase-1 promoter by thyroid hormone. Mol Pharmacol. 2006 Sep;70(3):793-800.
2 Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
3 Endocrine disruption potentials of organophosphate flame retardants and related mechanisms in H295R and MVLN cell lines and in zebrafish. Aquat Toxicol. 2012 Jun 15;114-115:173-81.
4 TEGDMA modulates glutathione transferase P1 activity in gingival fibroblasts. J Dent Res. 2004 Dec;83(12):914-9.
5 Prolonged copper depletion induces expression of antioxidants and triggers apoptosis in SH-SY5Y neuroblastoma cells. Cell Mol Life Sci. 2003 Aug;60(8):1733-43.
6 Thyroid hormone responsive genes in cultured human fibroblasts. J Clin Endocrinol Metab. 2005 Feb;90(2):936-43.
7 Triclosan treatment decreased the antitumor effect of sorafenib on hepatocellular carcinoma cells. Onco Targets Ther. 2018 May 18;11:2945-2954.
8 Organophosphorus flame retardants impair intracellular lipid metabolic function in human hepatocellular cells. Chem Res Toxicol. 2019 Jun 17;32(6):1250-1258.
9 Activated thyroid hormone receptor modulates dioxin-inducible aryl hydrocarbon receptor-mediated CYP1A1 induction in human hepatocytes but not in human hepatocarcinoma HepG2 cells. Toxicol Lett. 2017 Jun 5;275:77-82.
10 Species-specific differences in peroxisome proliferation, catalase, and SOD2 upregulation as well as toxicity in human, mouse, and rat hepatoma cells induced by the explosive and environmental pollutant 2,4,6-trinitrotoluene. Environ Toxicol. 2017 Mar;32(3):989-1006.
11 Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanisms. Free Radic Biol Med. 2014 Feb;67:171-87.
12 Assessment of the inhibition potential of Licochalcone A against human UDP-glucuronosyltransferases. Food Chem Toxicol. 2016 Apr;90:112-22.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.