Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00184)
Xenobiotics Name
Calcitriol
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
5280453
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Tartrate-resistant acid ATPase (ACP5) DME Info Homo sapiens [1]
Aldehyde dehydrogenase 5 (ALDHX) DME Info Homo sapiens [2]
Butyrylcholine esterase (BCHE) DME Info Homo sapiens [3]
Vitamin D(3) 25-hydroxylase (CYP27A1) DME Info Homo sapiens [2]
Cytochrome P450 2S1 (CYP2S1) DME Info Homo sapiens [4]
Cytochrome P450 4B1 (CYP4B1) DME Info Homo sapiens [5]
Short-chain dehydrogenase/reductase retSDR1 (DHRS3) DME Info Homo sapiens [4]
Thymidylate kinase (DTYMK) DME Info Homo sapiens [3]
Dimethylaniline oxidase 2 (FMO2) DME Info Homo sapiens [2]
Hexosephosphate aminotransferase 2 (GFPT2) DME Info Homo sapiens [2]
Gamma-Glu-X carboxypeptidase (GGH) DME Info Homo sapiens [3]
L-glutamine amidohydrolase (GLS) DME Info Homo sapiens [4]
Glutamine synthetase (GLUL) DME Info Homo sapiens [4]
Hypoxanthine phosphoribosyltransferase (HPRT1) DME Info Homo sapiens [3]
N-acetyltransferase 2 (NAT2) DME Info Homo sapiens [5]
Phosphoribosylformylglycinamidine synthase (PFAS) DME Info Homo sapiens [3]
Sulfotransferase 1B1 (SULT1B1) DME Info Homo sapiens [5]
Transglutaminase K (TGM1) DME Info Homo sapiens [4]
Transglutaminase E (TGM3) DME Info Homo sapiens [3]
Thymidylate synthase (TYMS) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 2B15 (UGT2B15) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 2B17 (UGT2B17) DME Info Homo sapiens [3]
DME(s) Induced by This Xenobiotics
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [6], [3]
Arachidonate 5-lipoxygenase (ALOX5) DME Info Homo sapiens [7]
Alkaline phosphatase (ALPL) DME Info Homo sapiens [8]
Copper amine oxidase (AOC3) DME Info Homo sapiens [2]
Arylsulfatase A (ARSA) DME Info Homo sapiens [3]
Carbonic anhydrase II (CA2) DME Info Homo sapiens [2], [4]
Cytidine aminohydrolase (CDA) DME Info Homo sapiens [4]
Choline dehydrogenase (CHDH) DME Info Homo sapiens [2]
Cholesterol desmolase (CYP11A1) DME Info Homo sapiens [3]
Aromatase (CYP19A1) DME Info Homo sapiens [9]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [5]
Vitamin D(3) 24-hydroxylase (CYP24A1) DME Info Homo sapiens [10], [11]
Retinoic acid 4-hydroxylase 26A1 (CYP26A1) DME Info Homo sapiens [5]
Retinoic acid 4-hydroxylase 26B1 (CYP26B1) DME Info Homo sapiens [2], [4]
Calcidiol 1-monooxygenase (CYP27B1) DME Info Homo sapiens [12]
Cytochrome P450 2A6 (CYP2A6) DME Info Homo sapiens [3]
Mephenytoin 4-hydroxylase (CYP2C19) DME Info Homo sapiens [5]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [13]
Cytochrome P450 3A5 (CYP3A5) DME Info Homo sapiens [5]
Cytochrome P450 3A7 (CYP3A7) DME Info Homo sapiens [6], [4]
Delta(24)-sterol reductase (DHCR24) DME Info Homo sapiens [2]
Dipeptidyl peptidase IV (DPP4) DME Info Homo sapiens [2]
Fatty acid desaturase 1 (FADS1) DME Info Homo sapiens [3]
Glutathione S-transferase mu-1 (GSTM1) DME Info Homo sapiens [3]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info Homo sapiens [3]
Estradiol 17-beta-dehydrogenase 2 (HSD17B2) DME Info Homo sapiens [3]
Dihydrotestosterone oxidoreductase (HSD3B1) DME Info Homo sapiens [3]
Monoamine oxidase type B (MAO-B) DME Info Homo sapiens [2]
Methylsterol monooxygenase 1 (MSMO1) DME Info Homo sapiens [2], [3]
Methylenetetrahydrofolate reductase (MTHFR) DME Info Homo sapiens [3]
N-acetyltransferase 1 (NAT1) DME Info Homo sapiens [3]
Cysteinyl-conjugate N-acetyltransferase (NAT8) DME Info Homo sapiens [5]
Proline dehydrogenase 1 (PRODH) DME Info Homo sapiens [3]
Prostaglandin G/H synthase 1 (COX-1) DME Info Homo sapiens [14], [15]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [4]
Sulfotransferase 2B1 (SULT2B1) DME Info Homo sapiens [2]
Transglutaminase H (TGM2) DME Info Homo sapiens [2], [3]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [4]
Thymidine phosphorylase (TYMP) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [3], [5]
Uracil phosphoribosyltransferase (UPRT) DME Info Homo sapiens [4]
References
1 Decreased blood lead levels after calcitriol treatment in hemodialysis patients with secondary hyperparathyroidism. Bone. 2011 Dec;49(6):1306-10.
2 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
3 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
4 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
5 Vitamin D3 transactivates the zinc and manganese transporter SLC30A10 via the Vitamin D receptor. J Steroid Biochem Mol Biol. 2016 Oct;163:77-87.
6 Expression profiling in squamous carcinoma cells reveals pleiotropic effects of vitamin D3 analog EB1089 signaling on cell proliferation, differentiation, and immune system regulation. Mol Endocrinol. 2002 Jun;16(6):1243-56.
7 New vitamin D receptor agonists with decreased metabolic stability. Biochem Pharmacol. 2000 Jun 15;59(12):1597-601.
8 Effects of 25-hydroxyvitamin D(3) on proliferation and osteoblast differentiation of human marrow stromal cells require CYP27B1/1alpha-hydroxylase. J Bone Miner Res. 2011 May;26(5):1145-53.
9 Regulation of aromatase and 5alpha-reductase by 25-hydroxyvitamin D(3), 1alpha,25-dihydroxyvitamin D(3), dexamethasone and progesterone in prostate cancer cells. J Steroid Biochem Mol Biol. 2005 Feb;94(1-3):151-7.
10 Studies on the mechanisms of superagonistic pro-differentiating activities of side-chain modified analogs of vitamin D2. Oncol Rep. 2012 Sep;28(3):1110-6.
11 Genistein potentiates the growth inhibitory effects of 1,25-dihydroxyvitamin D3 in DU145 human prostate cancer cells: role of the direct inhibition of CYP24 enzyme activity. Mol Cell Endocrinol. 2005 Sep 28;241(1-2):49-61.
12 Vitamin D(3) metabolism in human glioblastoma multiforme: functionality of CYP27B1 splice variants, metabolism of calcidiol, and effect of calcitriol. Clin Cancer Res. 2005 Aug 1;11(15):5370-80.
13 Possible inhibitory mechanism of Curcuma drugs on CYP3A4 in 1alpha,25 dihydroxyvitamin D3 treated Caco-2 cells. Int J Pharm. 2007 Jun 7;337(1-2):169-77.
14 Induction of differentiation of myeloid leukemia cells in primary culture in response to lithocholic acid acetate, a bile acid derivative, and cooperative effects with another differentiation inducer, cotylenin A. Leuk Res. 2008 Jul;32(7):1112-23.
15 Immediate up-regulation of the calcium-binding protein S100P and its involvement in the cytokinin-induced differentiation of human myeloid leukemia cells. Biochim Biophys Acta. 2005 Sep 10;1745(2):156-65.

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