General Information of Xenobiotics (ID: XEO00223)
Xenobiotics Name
Rifampin
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
10901569
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 2A13 (CYP2A13) DME Info Homo sapiens [1], [2]
Cytochrome P450 2C18 (CYP2C18) DME Info Homo sapiens [3]
Cytochrome P450 2F1 (CYP2F1) DME Info Homo sapiens [4]
NADPH-dependent oxidoreductase (nfrA) DME Info Staphylococcus aureus [5]
DME(s) Induced by This Xenobiotics
Alcohol dehydrogenase class-I gamma (ADH1C) DME Info Homo sapiens [6]
Small intestine reductase (AKR1B10) DME Info Homo sapiens [7]
Carboxylesterase 1 (CES1) DME Info Homo sapiens [8]
Carboxylesterase 2 (CES2) DME Info Homo sapiens [9]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [10]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [11], [12]
Vitamin D(3) 24-hydroxylase (CYP24A1) DME Info Homo sapiens [13], [14]
Vitamin D(3) 25-hydroxylase (CYP27A1) DME Info Homo sapiens [15]
Cytochrome P450 2A6 (CYP2A6) DME Info Homo sapiens [16], [9]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [17]
Mephenytoin 4-hydroxylase (CYP2C19) DME Info Homo sapiens [18]
Cytochrome P450 2C8 (CYP2C8) DME Info Homo sapiens [19], [20]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [21]
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [22], [6]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [11], [23]
Cytochrome P450 3A5 (CYP3A5) DME Info Homo sapiens [24]
Cytochrome P450 3A7 (CYP3A7) DME Info Homo sapiens [25]
Glutathione S-transferase alpha-1 (GSTA1) DME Info Homo sapiens [24]
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [26]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [27], [28]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [11], [29]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info Homo sapiens [30], [31]
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME Info Homo sapiens [32]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info Homo sapiens [14]
References
1 Effects of resveratrol on endothelial progenitor cells and their contributions to reendothelialization in intima-injured rats. J Cardiovasc Pharmacol. 2006 May;47(5):711-21.
2 Differential regulation of proliferation, cell cycle control and gene expression in cultured human aortic and pulmonary artery endothelial cells by resveratrol. Int J Mol Med. 2010 Nov;26(5):743-9.
3 Anti-tumor properties of methoxylated analogues of resveratrol in malignant MCF-7 but not in non-tumorigenic MCF-10A mammary epithelial cell lines. Toxicology. 2019 Jun 15;422:35-43.
4 High-throughput library screening identifies two novel NQO1 inducers in human lung cells. Am J Respir Cell Mol Biol. 2012 Mar;46(3):365-71.
5 Citropin 1.1-treated central venous catheters improve the efficacy of hydrophobic antibiotics in the treatment of experimental staphylococcal catheter-related infection. Peptides. 2006 Jun;27(6):1210-6.
6 Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice. J Pharmacol Exp Ther. 2010 Oct;335(1):149-54.
7 Interactive gene expression pattern in prostate cancer cells exposed to phenolic antioxidants. Life Sci. 2002 Mar 1;70(15):1821-39.
8 Apoptosis induced by capsaicin and resveratrol in colon carcinoma cells requires nitric oxide production and caspase activation. Anticancer Res. 2009 Oct;29(10):3733-40.
9 Differential effects of resveratrol on androgen-responsive LNCaP human prostate cancer cells in vitro and in vivo. Carcinogenesis. 2008 Oct;29(10):2001-10.
10 Anti-nephrolithic potential of resveratrol via inhibition of ROS, MCP-1, hyaluronan and osteopontin in vitro and in vivo. Pharmacol Rep. 2013;65(4):970-9.
11 Resveratrol in human hepatoma HepG2 cells: metabolism and inducibility of detoxifying enzymes. Drug Metab Dispos. 2007 May;35(5):699-703.
12 Effects of endocrine disruptors on genes associated with 17beta-estradiol metabolism and excretion. Steroids. 2008 Nov;73(12):1242-51.
13 Resveratrol exerts its antiproliferative effect on HepG2 hepatocellular carcinoma cells, by inducing cell cycle arrest, and NOS activation. Biochim Biophys Acta. 2006 Nov;1760(11):1657-66.
14 Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation. 2002 Sep 24;106(13):1652-8.
15 Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol. Nitric Oxide. 2013 Aug 1;32:29-35.
16 Differences in the activities of resveratrol and ascorbic acid in protection of ethanol-induced oxidative DNA damage in human peripheral lymphocytes. Food Chem Toxicol. 2012 Feb;50(2):168-74.
17 Mechanisms of ceramide-induced COX-2-dependent apoptosis in human ovarian cancer OVCAR-3 cells partially overlapped with resveratrol. J Cell Biochem. 2013 Aug;114(8):1940-54.
18 Impact of trans-resveratrol-sulfates and -glucuronides on endothelial nitric oxide synthase activity, nitric oxide release and intracellular reactive oxygen species. Molecules. 2014 Oct 17;19(10):16724-36.
19 Induction of quinone reductase NQO1 by resveratrol in human K562 cells involves the antioxidant response element ARE and is accompanied by nuclear translocation of transcription factor Nrf2. Med Chem. 2006 May;2(3):275-85.
20 Prevention of estrogen-DNA adduct formation in MCF-10F cells by resveratrol. Free Radic Biol Med. 2008 Jul 15;45(2):136-45.
21 Effects of hydroxylated resveratrol analogs on oxidative stress and cancer cells death in human acute T cell leukemia cell line: prooxidative potential of hydroxylated resveratrol analogs. Chem Biol Interact. 2014 Feb 25;209:96-110.
22 Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. J Med Chem. 2010 Jul 8;53(13):5033-43.
23 Resveratrol mediates anti-atherogenic effects on cholesterol flux in human macrophages and endothelium via PPARgama and adenosine. Eur J Pharmacol. 2013 Jan 5;698(1-3):299-309.
24 AMP-activated protein kinase mediates the antioxidant effects of resveratrol through regulation of the transcription factor FoxO1. FEBS J. 2014 Oct;281(19):4421-38.
25 Antioxidant activities of novel resveratrol analogs in breast cancer. J Biochem Mol Toxicol. 2018 Jan;32(1).
26 Resveratrol attenuates apoptosis of pulmonary microvascular endothelial cells induced by high shear stress and proinflammatory factors. Hum Cell. 2011 Sep;24(3):127-33.
27 Resveratrol modulates mRNA transcripts of genes related to redox metabolism and cell proliferation in non-small-cell lung carcinoma cells. Biol Chem. 2007 Feb;388(2):207-19.
28 Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4). J Physiol Pharmacol. 2009 Oct;60 Suppl 4:111-6.
29 Inhibition of CYP17A1 activity by resveratrol, piceatannol, and synthetic resveratrol analogs. Prostate. 2014 Jun;74(8):839-51.
30 Resveratrol stimulates nitric oxide production by increasing estrogen receptor alpha-Src-caveolin-1 interaction and phosphorylation in human umbilical vein endothelial cells. FASEB J. 2008 Jul;22(7):2185-97.
31 Pro-angiogenic effects of resveratrol in brain endothelial cells: nitric oxide-mediated regulation of vascular endothelial growth factor and metalloproteinases. J Cereb Blood Flow Metab. 2012 May;32(5):884-95.
32 Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.

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