Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00232)
Xenobiotics Name
Phenytoin
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
1775
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Glutathione S-transferase omega-1 (GSTO1) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [2]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [3]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [4]
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [5], [6]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [7]
Cytochrome P450 3A5 (CYP3A5) DME Info Homo sapiens [2]
Cytochrome P450 3A7 (CYP3A7) DME Info Homo sapiens [8]
Glutathione S-transferase alpha-1 (GSTA1) DME Info Homo sapiens [2]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [2]
References
1 Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone. Chem Biol Interact. 2003 Feb 1;143-144:503-13.
2 Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance. Hepatology. 2004 Oct;40(4):951-60.
3 Oxidative stress mechanisms do not discriminate between genotoxic and nongenotoxic liver carcinogens. Chem Res Toxicol. 2015 Aug 17;28(8):1636-46.
4 Human NAD(P)H:quinone oxidoreductase induction in human hepatoma cells after exposure to industrial acrylates, phenolics, and metals. Drug Metab Dispos. 1997 Feb;25(2):175-81.
5 Induction of CYP4F3 by benzene metabolites in human white blood cells in vivo in human promyelocytic leukemic cell lines and ex vivo in human blood neutrophils. Drug Metab Dispos. 2009 Feb;37(2):282-91.
6 Gene expression in benzene-exposed workers by microarray analysis of peripheral mononuclear blood cells: induction and silencing of CYP4F3A and regulation of DNA-dependent protein kinase catalytic subunit in DNA double strand break repair. Chem Biol Interact. 2010 Mar 19;184(1-2):207-11.
7 Xenobiotic CAR activators induce Dlk1-Dio3 locus noncoding RNA expression in mouse liver. Toxicol Sci. 2017 Aug 1;158(2):367-378.
8 Sensitivity of human dental pulp cells to eighteen chemical agents used for endodontic treatments in dentistry. Odontology. 2013 Jan;101(1):43-51.

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