Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00339)
Xenobiotics Name
Arsenic trioxide
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
261004
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Acetyl-CoA synthetase (ACSS2) DME Info Homo sapiens [1]
Aldo-keto reductase 1B1 (AKR1B1) DME Info Homo sapiens [2]
Aldehyde dehydrogenase 1 (ALDH1) DME Info Homo sapiens [3]
Aminomuconic semialdehyde dehydrogenase (ALDH12) DME Info Homo sapiens [4]
Alanyl aminopeptidase (ANPEP) DME Info Homo sapiens [5]
Asparagine synthetase (ASNS) DME Info Homo sapiens [6]
Beta,beta-carotene 15,15'-dioxygenase (BCO1) DME Info Homo sapiens [7]
Catalase (CAT) DME Info Homo sapiens [8]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [9]
Vitamin D(3) 24-hydroxylase (CYP24A1) DME Info Homo sapiens [10]
Dipeptidyl peptidase IV (DPP4) DME Info Homo sapiens [11], [12]
Glutamine amidotransferase (GMPS) DME Info Homo sapiens [13]
Cellular glutathione peroxidase (GPX1) DME Info Homo sapiens [14]
Glutathione S-transferase theta-1 (GSTT1) DME Info Homo sapiens [15]
Estradiol 17-beta-dehydrogenase 2 (HSD17B2) DME Info Homo sapiens [2]
Methylsterol monooxygenase 1 (MSMO1) DME Info Homo sapiens [16], [17]
Methionine-R-sulfoxide reductase B2 (MSRB2) DME Info Homo sapiens [18]
Metallothionein-1A (MT1A) DME Info Homo sapiens [19]
Vitamin B12 methionine synthase (MTR) DME Info Homo sapiens [17]
Nitric oxide synthase endothelial (NOS3) DME Info Homo sapiens [20]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [21]
Deoxy-5'-nucleotidase 1 (NT5C) DME Info Homo sapiens [22]
Ecto-5'-nucleotidase (NT5E) DME Info Homo sapiens [23]
Phosphorylethanolamine transferase (PCYT2) DME Info Homo sapiens [1]
Phosphodiesterase 7B (PDE7B) DME Info Homo sapiens [24]
Purine nucleoside phosphorylase (PNP) DME Info Homo sapiens [6]
Prostaglandin G/H synthase 1 (COX-1) DME Info Homo sapiens [24]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [25]
Superoxide dismutase 1 (SOD1) DME Info Homo sapiens [14]
Steroid 5-alpha-reductase 1 (SRD5A1) DME Info Homo sapiens [26]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [27]
Thymidylate synthase (TYMS) DME Info Homo sapiens [28], [29]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info Homo sapiens [30]
DME(s) Induced by This Xenobiotics
Alcohol dehydrogenase class-I alpha (ADH1A) DME Info Homo sapiens [15]
Aldo-keto reductase 1C2 (AKR1C2) DME Info Homo sapiens [24], [22]
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [24]
Aldehyde dehydrogenase 5 (ALDHX) DME Info Homo sapiens [23]
Copper amine oxidase (AOC3) DME Info Homo sapiens [31]
Butyrylcholine esterase (BCHE) DME Info Homo sapiens [15]
NADPH-dependent carbonyl reductase 1 (CBR1) DME Info Homo sapiens [32]
Cathepsin A (CTSA) DME Info Homo sapiens [15], [18]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [30], [1]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [15]
Cytochrome P450 3A43 (CYP3A43) DME Info Homo sapiens [7]
Dihydrothymine dehydrogenase (DPYD) DME Info Homo sapiens [23]
Bifunctional epoxide hydrolase 2 (EPHX2) DME Info Homo sapiens [30]
Eosinophil peroxidase (EPX) DME Info Homo sapiens [33], [7]
Galactose kinase (GALK1) DME Info Homo sapiens [13]
Gamma-Glu-X carboxypeptidase (GGH) DME Info Homo sapiens [31]
L-glutamine amidohydrolase (GLS) DME Info Homo sapiens [15]
Glutamine synthetase (GLUL) DME Info Homo sapiens [17]
Glutathione reductase (GSR) DME Info Homo sapiens [34], [35]
Glutathione S-transferase alpha-1 (GSTA1) DME Info Homo sapiens [36], [15]
Glutathione S-transferase mu-1 (GSTM1) DME Info Homo sapiens [15], [23]
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [37]
Peroxisomal multifunctional enzyme 2 (HSD17B4) DME Info Homo sapiens [6]
Iduronate 2-sulfatase (IDS) DME Info Homo sapiens [7]
Monoamine oxidase type A (MAO-A) DME Info Homo sapiens [23], [7]
Metallothionein-2A (MT2A) DME Info Homo sapiens [38]
NADH-ubiquinone oxidoreductase 49 kDa (NDUFS2) DME Info Homo sapiens [23]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [39]
Phosphoribosylformylglycinamidine synthase (PFAS) DME Info Homo sapiens [40]
Phosphoglucomutase 1 (PGM1) DME Info Homo sapiens [6]
Amidophosphoribosyltransferase (GPAT) DME Info Homo sapiens [23]
Prostaglandin reductase 1 (PTGR1) DME Info Homo sapiens [23]
Sulfotransferase 1A1 (SULT1A1) DME Info Homo sapiens [23]
Sulfotransferase 1A2 (SULT1A2) DME Info Homo sapiens [23]
Sulfotransferase 1C4 (SULT1C4) DME Info Homo sapiens [24]
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME Info Homo sapiens [15], [3]
Uridine phosphorylase 1 (UPP1) DME Info Homo sapiens [1]
References
1 Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. Oncotarget. 2016 Dec 13;7(50):83359-83377.
2 Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
3 A comprehensive analysis of Wnt/beta-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer. Ren Fail. 2018 Nov;40(1):331-339.
4 Successful validation of genomic biomarkers for human immunotoxicity in Jurkat T cells in vitro. J Appl Toxicol. 2015 Jul;35(7):831-41.
5 Detection of gene expression alteration of myeloma cells treated with arsenic trioxide. Zhonghua Xue Ye Xue Za Zhi. 2005 Apr;26(4):209-13.
6 Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
7 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
8 Different administration patterns of docosahexaenoic acid in combating cytotoxic manifestations due to arsenic trioxide (acute promyelocytic leukemia drug) induced redox imbalance in hepatocytes. Prostaglandins Other Lipid Mediat. 2018 May;136:64-75.
9 Modulation of cellular response to arsenic trioxide toxicity by resveratrol. ACS Omega. 2018 May 31;3(5):5511-5515.
10 19-Nor-1,25(OH)2D2 (a novel, noncalcemic vitamin D analogue), combined with arsenic trioxide, has potent antitumor activity against myeloid leukemia. Cancer Res. 2005 Mar 15;65(6):2488-97.
11 Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling. Neurotoxicology. 2015 Sep;50:56-70.
12 Effect of subchronic exposure to inorganic arsenic on the structure and function of the intestinal epithelium. Toxicol Lett. 2018 Apr;286:80-88.
13 Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells. J Proteome Res. 2009 Jun;8(6):3006-19.
14 Role of oxidative stress in the apoptosis of hepatocellular carcinoma induced by combination of arsenic trioxide and ascorbic acid. Acta Pharmacol Sin. 2006 Aug;27(8):1078-84.
15 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
16 Combination of arsenic trioxide and Dasatinib: a new strategy to treat Philadelphia chromosome-positive acute lymphoblastic leukaemia. J Cell Mol Med. 2018 Mar;22(3):1614-1626.
17 Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
18 Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo. Br J Haematol. 2005 Mar;128(5):636-44.
19 Arsenic trioxide (ATO) influences the gene expression of metallothioneins in human glioblastoma cells. Biol Trace Elem Res. 2012 Dec;149(3):331-9.
20 Endothelial gap junctions are down-regulated by arsenic trioxide. Eur J Pharmacol. 2007 Aug 13;569(1-2):29-36.
21 miR-155/BACH1 signaling pathway in human lung adenocarcinoma cell death induced by arsenic trioxide. Sichuan Da Xue Xue Bao Yi Xue Ban. 2017 Nov;48(6):828-833.
22 Aberrantly expressed genes in HaCaT keratinocytes chronically exposed to arsenic trioxide. Biomark Insights. 2011 Feb 8;6:7-16.
23 Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
24 Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
25 Mitophagy inhibits proliferation by decreasing cyclooxygenase-2 (COX-2) in arsenic trioxide-treated HepG2 cells. Environ Toxicol Pharmacol. 2016 Jul;45:212-21.
26 Arsenic trioxide and cisplatin synergism increase cytotoxicity in human ovarian cancer cells: therapeutic potential for ovarian cancer. Cancer Sci. 2009 Dec;100(12):2459-64.
27 Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide. Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12288-93.
28 Arsenic trioxide suppresses thymidylate synthase in 5-FU-resistant colorectal cancer cell line HT29 In Vitro re-sensitizing cells to 5-FU. Anticancer Res. 2010 Apr;30(4):1157-62.
29 Downregulation of thymidylate synthase with arsenic trioxide in lung adenocarcinoma. Int J Oncol. 2014 Jun;44(6):2093-102.
30 Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
31 Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. Environ Toxicol. 2016 Mar;31(3):314-28.
32 Carbonyl reductase 1 offers a novel therapeutic target to enhance leukemia treatment by arsenic trioxide. Cancer Res. 2012 Aug 15;72(16):4214-24.
33 Role of NADPH oxidase in arsenic-induced reactive oxygen species formation and cytotoxicity in myeloid leukemia cells. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4578-83.
34 An approach to elucidate potential mechanism of renal toxicity of arsenic trioxide. Exp Hematol. 2007 Feb;35(2):252-62.
35 Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line. Mol Cancer Ther. 2009 May;8(5):1197-206.
36 Atrazine potentiation of arsenic trioxide-induced cytotoxicity and gene expression in human liver carcinoma cells (HepG2). Mol Cell Biochem. 2001 Jun;222(1-2):49-59.
37 Arsenic trioxide inhibits DNA methyltransferase and restores methylation-silenced genes in human liver cancer cells. Hum Pathol. 2006 Mar;37(3):298-311.
38 Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2). Cell Mol Biol (Noisy-le-grand). 2003 Nov;49(7):1071-9.
39 The role of NF-B in PARP-inhibitor-mediated sensitization and detoxification of arsenic trioxide in hepatocellular carcinoma cells. J Toxicol Sci. 2015 Jun;40(3):349-63.
40 Synergistic effects of arsenic trioxide combined with ascorbic acid in human osteosarcoma MG-63 cells: a systems biology analysis. Eur Rev Med Pharmacol Sci. 2014;18(24):3877-88.

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