Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00447)
Xenobiotics Name
Benzoic acid
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
243
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Catalase (CAT) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Aldo-keto reductase 1B1 (AKR1B1) DME Info Homo sapiens [2]
Small intestine reductase (AKR1B10) DME Info Homo sapiens [2]
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [2]
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [2]
Glutathione reductase (GSR) DME Info Homo sapiens [2]
Glutathione S-transferase alpha-1 (GSTA1) DME Info Homo sapiens [3]
Myeloperoxidase (MPO) DME Info Homo sapiens [4]
Metallothionein-1A (MT1A) DME Info Homo sapiens [5]
Metallothionein-2A (MT2A) DME Info Homo sapiens [5]
Nitric oxide synthase endothelial (NOS3) DME Info Homo sapiens [6]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [2]
Prostaglandin reductase 1 (PTGR1) DME Info Homo sapiens [2]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [2]
References
1 In vitro effects of quercetin on oxidative stress mediated in human erythrocytes by benzoic acid and citric acid. Folia Biol (Krakow). 2014;62(1):59-66.
2 Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. Toxicol Sci. 2010 Sep;117(1):81-9.
3 Benzoic acid derivatives induce recovery of catalytic activity in the partially inactive Met208Lys mutant of human glutathione transferase A1-1. J Mol Biol. 1999 May 14;288(4):787-800.
4 Differentiation between stoichiometric and anticatalytic antioxidant properties of benzoic acid analogues: a structure/redox potential relationship study. Chem Biol Interact. 2013 Nov 25;206(2):194-203.
5 A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells. Cutan Ocul Toxicol. 2010 Sep;29(3):171-92.
6 A blend of polyphenolic compounds explains the stimulatory effect of red wine on human endothelial NO synthase. Nitric Oxide. 2005 Mar;12(2):97-104.

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