Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00582)
Xenobiotics Name
Diethyltoluamide
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 3 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
4284
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Acetylcholinesterase (ACHE) DME Info Homo sapiens [1]
Butyrylcholine esterase (BCHE) DME Info Homo sapiens [1]
Lauric acid omega-hydroxylase (CYP4A11) DME Info Homo sapiens [2]
Dihydrotestosterone oxidoreductase (HSD3B1) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Microsomal cytochrome MCB5 (CYB5A) DME Info Homo sapiens [2]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [2]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [3], [2]
Cytochrome P450 2A13 (CYP2A13) DME Info Homo sapiens [2]
Cytochrome P450 2A6 (CYP2A6) DME Info Homo sapiens [3], [2]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [3], [2]
Cytochrome P450 2C8 (CYP2C8) DME Info Homo sapiens [2]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [2]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [3], [2]
Cytochrome P450 3A43 (CYP3A43) DME Info Homo sapiens [2]
Cytochrome P450 3A5 (CYP3A5) DME Info Homo sapiens [2]
Cytochrome P450 3A7 (CYP3A7) DME Info Homo sapiens [2]
Glutathione S-transferase alpha-2 (GSTA2) DME Info Homo sapiens [2]
NADPH-cytochrome P450 reductase (CPR) DME Info Homo sapiens [2]
References
1 In vitro kinetic interactions of DEET, pyridostigmine and organophosphorus pesticides with human cholinesterases. Chem Biol Interact. 2011 Apr 25;190(2-3):79-83.
2 Impact of environmental chemicals on the transcriptome of primary human hepatocytes: potential for health effects. J Biochem Mol Toxicol. 2016 Aug;30(8):375-95.
3 Enzyme induction and cytotoxicity in human hepatocytes by chlorpyrifos and N,N-diethyl-m-toluamide (DEET). Drug Metabol Drug Interact. 2008;23(3-4):237-60.

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