Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00622)
Xenobiotics Name
AM-80
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 2 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
108143
DME(s) Modulated by This Xenobiotics
DME(s) Induced by This Xenobiotics
Cathepsin A (CTSA) DME Info Homo sapiens [1]
Glutathione S-transferase mu-1 (GSTM1) DME Info Homo sapiens [2], [3]
Glutathione S-transferase omega-1 (GSTO1) DME Info Homo sapiens [4], [5]
Metallothionein-1A (MT1A) DME Info Homo sapiens [6]
NADPH-cytochrome P450 reductase (CPR) DME Info Homo sapiens [7]
Putrescine acetyltransferase (SSAT1) DME Info Homo sapiens [2]
Transglutaminase X (TGM5) DME Info Homo sapiens [8]
References
1 Comparison of Aristolochic acid I derived DNA adduct levels in human renal toxicity models. Toxicology. 2019 May 15;420:29-38.
2 Transcriptomic responses of cancerous and noncancerous human colon cells to sulforaphane and selenium. Chem Res Toxicol. 2014 Mar 17;27(3):377-86.
3 Regulation of the expression of renal drug transporters in KEAP1-knockdown human tubular cells. Toxicol In Vitro. 2015 Aug;29(5):884-92.
4 Thioredoxin reductase in human hepatoma cells is transcriptionally regulated by sulforaphane and other electrophiles via an antioxidant response element. J Nutr. 2003 Sep;133(9):2721-7.
5 Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation. Carcinogenesis. 2003 Mar;24(3):497-503.
6 Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanisms. Free Radic Biol Med. 2014 Feb;67:171-87.
7 Major differences among chemopreventive organoselenocompounds in the sustained elevation of cytoprotective genes. J Biochem Mol Toxicol. 2012 Sep;26(9):344-53.
8 Sulforaphane-induced apoptosis in human leukemia HL-60 cells through extrinsic and intrinsic signal pathways and altering associated genes expression assayed by cDNA microarray. Environ Toxicol. 2017 Jan;32(1):311-328.

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