Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00740)
Xenobiotics Name
Lindane
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
727
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cholesterol desmolase (CYP11A1) DME Info Homo sapiens [1]
Aromatase (CYP19A1) DME Info Homo sapiens [2]
Cytochrome P450 2D6 (CYP2D6) DME Info Homo sapiens [3]
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [3]
Beta-HSD adrenal and gonadal type (HSD3B2) DME Info Homo sapiens [1]
Sulfotransferase 2A1 (SULT2A1) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Aminomuconic semialdehyde dehydrogenase (ALDH12) DME Info Homo sapiens [4]
Asparagine synthetase (ASNS) DME Info Homo sapiens [4]
Catalase (CAT) DME Info Homo sapiens [5]
Vitamin D(3) 25-hydroxylase (CYP27A1) DME Info Homo sapiens [6]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [7]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [7]
Cytochrome P450 3A7 (CYP3A7) DME Info Homo sapiens [8]
Glutathione reductase (GSR) DME Info Homo sapiens [9]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [10]
Nitric oxide synthase endothelial (NOS3) DME Info Homo sapiens [11]
References
1 Steroidogenic gene expression in H295R cells and the human adrenal gland: adrenotoxic effects of lindane in vitro. J Appl Toxicol. 2006 Nov-Dec;26(6):484-92.
2 Aromatase activity modulation by lindane and bisphenol-A in human placental JEG-3 and transfected kidney E293 cells. Toxicol In Vitro. 2003 Aug;17(4):413-22.
3 Xenobiotic-metabolizing cytochromes p450 in human white adipose tissue: expression and induction. Drug Metab Dispos. 2010 Apr;38(4):679-86.
4 Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
5 Comparative effect of topical application of lindane and permethrin on oxidative stress parameters in adult scabies patients. Clin Biochem. 2007 Nov;40(16-17):1321-4.
6 Organochloride pesticides modulated gut microbiota and influenced bile acid metabolism in mice. Environ Pollut. 2017 Jul;226:268-276.
7 A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides. Biochem Pharmacol. 2004 Dec 15;68(12):2347-58.
8 Hierarchical cluster analysis of environmental pollutants through P450 induction in cultured hepatic cells. Ecotoxicol Environ Saf. 1996 Aug;34(3):205-15.
9 Oxidative stress mechanisms do not discriminate between genotoxic and nongenotoxic liver carcinogens. Chem Res Toxicol. 2015 Aug 17;28(8):1636-46.
10 Plasmatic concentration of organochlorine lindane acts as metabolic disruptors in HepG2 liver cell line by inducing mitochondrial disorder. Toxicol Appl Pharmacol. 2013 Oct 15;272(2):325-34.
11 Organochlorine pesticide-mediated induction of NADPH oxidase and nitric-oxide synthase in endothelial cell. J Clin Diagn Res. 2017 Jan;11(1):BC09-BC12.

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