Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00821)
Xenobiotics Name
Tobacco smoke pollution
Xenobiotics Type
Natural Product(s), Extract(s) or Medicine(s)
Classification
Natural Mixture
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Alcohol dehydrogenase class-I beta (ADH1B) DME Info Homo sapiens [1]
Gastric alcohol dehydrogenase (ADH7) DME Info Homo sapiens [1]
Aldehyde dehydrogenase 2 (ALDH2) DME Info Homo sapiens [2]
Aldehyde oxidase (AOX1) DME Info Homo sapiens [3]
Adenine phosphoribosyltransferase (APRT) DME Info Homo sapiens [2]
Catalase (CAT) DME Info Homo sapiens [2]
Serine sulfhydrase (CBS) DME Info Homo sapiens [4]
Aromatase (CYP19A1) DME Info Homo sapiens [5]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [6]
Cytochrome P450 2C18 (CYP2C18) DME Info Homo sapiens [7]
Vitamin D 25-hydroxylase (CYP2R1) DME Info Homo sapiens [8]
Cytochrome P450 3A5 (CYP3A5) DME Info Homo sapiens [5]
Cytochrome P450 4B1 (CYP4B1) DME Info Homo sapiens [5]
Delta(24)-sterol reductase (DHCR24) DME Info Homo sapiens [9]
Dihydrothymine dehydrogenase (DPYD) DME Info Homo sapiens [3]
Galactose kinase (GALK1) DME Info Homo sapiens [4]
Glutamine synthetase (GLUL) DME Info Homo sapiens [4], [10]
Glutathione reductase (GSR) DME Info Homo sapiens [11]
Glutathione S-transferase alpha-1 (GSTA1) DME Info Homo sapiens [12]
Glutathione S-transferase mu-1 (GSTM1) DME Info Homo sapiens [9]
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [2]
Histamine N-methyltransferase (HNMT) DME Info Homo sapiens [13]
Estradiol 17-beta-dehydrogenase 2 (HSD17B2) DME Info Homo sapiens [9]
Monoamine oxidase type A (MAO-A) DME Info Homo sapiens [14]
Microsomal glutathione S-transferase 2 (MGST2) DME Info Homo sapiens [2]
Neprilysin (MME) DME Info Homo sapiens [15]
Metallothionein-1A (MT1A) DME Info Homo sapiens [16]
Ecto-5'-nucleotidase (NT5E) DME Info Homo sapiens [11]
Phosphorylethanolamine transferase (PCYT2) DME Info Homo sapiens [17]
NADPH-cytochrome P450 reductase (CPR) DME Info Homo sapiens [2]
Superoxide dismutase 1 (SOD1) DME Info Homo sapiens [18]
Sulfotransferase 1E1 (SULT1E1) DME Info Homo sapiens [2]
Transglutaminase H (TGM2) DME Info Homo sapiens [19]
Transglutaminase E (TGM3) DME Info Homo sapiens [20]
DME(s) Induced by This Xenobiotics
Small intestine reductase (AKR1B10) DME Info Homo sapiens [10]
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [21]
Aldo-keto reductase 1C2 (AKR1C2) DME Info Homo sapiens [10]
Copper amine oxidase (AOC3) DME Info Homo sapiens [22]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [12], [5]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [23]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [24]
Calcidiol 1-monooxygenase (CYP27B1) DME Info Homo sapiens [25], [26]
Cytochrome P450 2A13 (CYP2A13) DME Info Homo sapiens [24]
Cytochrome P450 2A6 (CYP2A6) DME Info Homo sapiens [27]
Cytochrome P450 2S1 (CYP2S1) DME Info Homo sapiens [26]
Fatty acid desaturase 1 (FADS1) DME Info Homo sapiens [28]
Dimethylaniline oxidase 3 (FMO3) DME Info Homo sapiens [29]
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DME Info Homo sapiens [30]
Methionine-R-sulfoxide reductase B1 (MSRB1) DME Info Homo sapiens [31]
Metallothionein-2A (MT2A) DME Info Homo sapiens [32]
N-acetyltransferase 1 (NAT1) DME Info Homo sapiens [25]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [33]
Cytosolic phospholipase A2 (PLA2G4A) DME Info Homo sapiens [34]
Choline phosphatase 1 (PLD1) DME Info Homo sapiens [35]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [36]
UDP-glucuronosyltransferase 1A8 (UGT1A8) DME Info Homo sapiens [2]
Uridine phosphorylase 1 (UPP1) DME Info Homo sapiens [1]
References
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2 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
3 Discovery of potent carbonic anhydrase, acetylcholinesterase, and butyrylcholinesterase enzymes inhibitors: The new amides and thiazolidine-4-ones synthesized on an acetophenone base. J Biochem Mol Toxicol. 2017 Sep;31(9).
4 Assessment of a 72-hour repeated exposure to Swedish snus extract and total particulate matter from 3R4F cigarette smoke on gingival organotypic cultures. Food Chem Toxicol. 2019 Mar;125:252-270.
5 Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
6 Effect of theophylline on induced sputum inflammatory indices and neutrophil chemotaxis in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2002 May 15;165(10):1371-6.
7 Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline. Xenobiotica. 2001 Mar;31(3):135-51.
8 Hopeahainol A binds reversibly at the acetylcholinesterase (AChE) peripheral site and inhibits enzyme activity with a novel higher order concentration dependence. Chem Biol Interact. 2016 Nov 25;259(Pt B):78-84.
9 Comparative biological impacts of an aerosol from carbon-heated tobacco and smoke from cigarettes on human respiratory epithelial cultures: a systems toxicology assessment. Food Chem Toxicol. 2018 May;115:109-126.
10 Assessment of the impact of aerosol from a potential modified risk tobacco product compared with cigarette smoke on human organotypic oral epithelial cultures under different exposure regimens. Food Chem Toxicol. 2018 May;115:148-169.
11 Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors. Chem Biol Interact. 2004 Apr 15;147(3):331-40.
12 Chemical stresses fail to mimic the unfolded protein response resulting from luminal load with unfolded polypeptides. J Biol Chem. 2018 Apr 13;293(15):5600-5612.
13 Synthesis of new cyclic thioureas and evaluation of their metal-chelating activity, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase inhibition profiles. J Biochem Mol Toxicol. 2017 Jul;31(7).
14 Activity profiles of 309 ToxCast?chemicals evaluated across 292 biochemical targets. Toxicology. 2011 Mar 28;282(1-2):1-15.
15 Inhibition of human aromatase complex (CYP19) by antiepileptic drugs. Toxicol In Vitro. 2008 Feb;22(1):146-53.
16 Decrease in NADPH-cytochrome P450 reductase activity of the human heart, Liver and lungs in the presence of alpha-lipoic acid. Ann Nutr Metab. 2006;50(2):121-5.
17 Inhibition of glutathione S-transferases by thonningianin A, isolated from the African medicinal herb, Thonningia sanguinea, in vitro. Food Chem Toxicol. 2004 Sep;42(9):1401-8.
18 Synthesis and investigation of the conversion reactions of pyrimidine-thiones with nucleophilic reagent and evaluation of their acetylcholinesterase, carbonic anhydrase inhibition, and antioxidant activities. J Biochem Mol Toxicol. 2018 Feb;32(2).
19 Expression and kinetic properties of a recombinant 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzyme of human liver. J Biochem. 1995 Aug;118(2):285-90.
20 Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78.
21 Titanium dioxide nanoparticles induce COX-2 expression through ROS generation in human periodontal ligament cells. J Toxicol Sci. 2019;44(5):335-345.
22 The human placental proteome is affected by maternal smoking. Reprod Toxicol. 2016 Aug;63:22-31.
23 Tissue transglutaminase serves as an inhibitor of apoptosis by cross-linking caspase 3 in thapsigargin-treated cells. Mol Cell Biol. 2006 Jan;26(2):569-79.
24 Effect of butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole on cytochrome P450 forms in cultured human hepatocytes. Xenobiotica. 2008 Jun;38(6):574-86.
25 The use of a unique co-culture model of fetoplacental steroidogenesis as a screening tool for endocrine disruptors: The effects of neonicotinoids on aromatase activity and hormone production. Toxicol Appl Pharmacol. 2017 Oct 1;332:15-24.
26 Effects of neonicotinoids on promoter-specific expression and activity of aromatase (CYP19) in human adrenocortical carcinoma (H295R) and primary umbilical vein endothelial (HUVEC) cells. Toxicol Sci. 2016 Jan;149(1):134-44.
27 5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5261-6.
28 Human cytochrome P450 1A1 is a novel target gene of liver X receptor alpha. Drug Metab Pharmacokinet. 2011;26(5):451-7.
29 The inducibility of human cytochrome P450 1A by environmental-relevant xenobiotics in the human hepatoma derived cell line HepG2. Environ Toxicol Pharmacol. 2009 Nov;28(3):370-8.
30 Combination of bioanalytical approaches and quantitative proteomics for the elucidation of the toxicity mechanisms associated to TiO2 nanoparticles exposure in human keratinocytes. Food Chem Toxicol. 2019 May;127:197-205.
31 Markers of electrophilic stress caused by chemically reactive metabolites in human hepatocytes. Drug Metab Dispos. 2008 May;36(5):816-23.
32 Potent upregulation of glutathione and NAD(P)H:quinone oxidoreductase 1 by alpha-lipoic acid in human neuroblastoma SH-SY5Y cells: protection against neurotoxicant-elicited cytotoxicity. Neurochem Res. 2008 May;33(5):790-800.
33 Cytoprotective effect of alpha-lipoic acid on paraquat-exposed human bronchial epithelial cells via activation of nuclear factor erythroid related factor-2 pathway. Biol Pharm Bull. 2013;36(5):802-11.
34 In vitro analysis of factors influencing CYP1A2 expression as potential determinants of interindividual variation. Pharmacol Res Perspect. 2017 Mar 2;5(2):e00299.
35 The effects of implant surface nanoscale features on osteoblast-specific gene expression. Biomaterials. 2009 Sep;30(25):4053-62.
36 Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells. Toxicol Sci. 2007 Mar;96(1):101-14.

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