Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00905)
Xenobiotics Name
Cylindrospermopsin
Xenobiotics Type
Health or Environmental Toxicant(s)
Classification
Biotoxin
Structure
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3D MOL 2D MOL
PubChem CID
135565888
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Alcohol dehydrogenase class-I alpha (ADH1A) DME Info Homo sapiens [1]
Alcohol dehydrogenase class-I beta (ADH1B) DME Info Homo sapiens [1]
Catalase (CAT) DME Info Homo sapiens [2]
Carboxylesterase 1 (CES1) DME Info Homo sapiens [3]
Cytochrome P450 2A13 (CYP2A13) DME Info Homo sapiens [3]
Cytochrome P450 2A6 (CYP2A6) DME Info Homo sapiens [3]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [1]
Cytochrome P450 2C8 (CYP2C8) DME Info Homo sapiens [1]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [1]
Cytochrome P450 2F1 (CYP2F1) DME Info Homo sapiens [3]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [1]
Cytochrome P450 3A43 (CYP3A43) DME Info Homo sapiens [3]
Cytochrome P450 3A7 (CYP3A7) DME Info Homo sapiens [3]
Glutathione S-transferase alpha-2 (GSTA2) DME Info Homo sapiens [3]
Methylsterol monooxygenase 1 (MSMO1) DME Info Homo sapiens [4]
Sulfotransferase 1A1 (SULT1A1) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 2B15 (UGT2B15) DME Info Homo sapiens [1]
UDP-glucuronosyltransferase 2B17 (UGT2B17) DME Info Homo sapiens [1]
UDP-glucuronosyltransferase 2B4 (UGT2B4) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Retinal dehydrogenase 2 (ALDH1A2) DME Info Homo sapiens [3]
Carboxylesterase 2 (CES2) DME Info Homo sapiens [3]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [4]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [5]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [3]
Methylarsonite methyltransferase N6AMT1 (N6AMT1) DME Info Homo sapiens [4]
N-acetyltransferase 1 (NAT1) DME Info Homo sapiens [3]
Tryptophan oxygenase (TRPO) DME Info Homo sapiens [4]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME Info Homo sapiens [3]
Uridine 5'-monophosphate synthase (UMPS) DME Info Homo sapiens [4]
Uridine phosphorylase 1 (UPP1) DME Info Homo sapiens [4]
References
1 Identification of key pathways involved in the toxic response of the cyanobacterial toxin cylindrospermopsin in human hepatic HepaRG cells. Toxicol In Vitro. 2019 Aug;58:69-77.
2 The role of the enzymatic antioxidant system in cylindrospermopsin-induced toxicity in human lymphocytes. Toxicol In Vitro. 2015 Aug;29(5):926-32.
3 Cylindrospermopsin induced transcriptional responses in human hepatoma HepG2 cells. Toxicol In Vitro. 2013 Sep;27(6):1809-19.
4 Modulation of chromatin remodelling induced by the freshwater cyanotoxin cylindrospermopsin in human intestinal caco-2 cells. PLoS One. 2014 Jun 12;9(6):e99121.
5 Genotoxic effects of the cyanobacterial hepatotoxin cylindrospermopsin in the HepG2 cell line. Arch Toxicol. 2011 Dec;85(12):1617-26.

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