Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00969)
Xenobiotics Name	Atrazine
Xenobiotics Type	Fungicide(s), Herbicide(s) or Insecticide(s)
Classification	Herbicide
Structure	<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=2256"></iframe>
Structure	3D MOL	2D MOL
PubChem CID	2256
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
	Alcohol dehydrogenase class-III (ADH5)	DME Info	Homo sapiens	[1]
	Succinate-semialdehyde dehydrogenase (ALDH5A1)	DME Info	Homo sapiens	[1]
	Cytosolic branched aminotransferase (BCAT1)	DME Info	Homo sapiens	[1]
	NADPH-dependent carbonyl reductase 1 (CBR1)	DME Info	Homo sapiens	[1]
	Cathepsin A (CTSA)	DME Info	Homo sapiens	[1]
	Aromatase (CYP19A1)	DME Info	Homo sapiens	[2]
	Cytochrome P450 3A4 (CYP3A4)	DME Info	Homo sapiens	[3]
	DOPA decarboxylase (DDC)	DME Info	Homo sapiens	[1]
	Delta(24)-sterol reductase (DHCR24)	DME Info	Homo sapiens	[1]
	Glutamyl-tRNA(Gln) amidotransferase B (GATB)	DME Info	Homo sapiens	[1]
	Hypoxanthine phosphoribosyltransferase (HPRT1)	DME Info	Homo sapiens	[1]
	Methionine-tRNA ligase mitochondrial (MARS2)	DME Info	Homo sapiens	[1]
	Methionine-R-sulfoxide reductase B1 (MSRB1)	DME Info	Homo sapiens	[1]
	Glutamine-dependent NAD(+) synthetase (NADSYN1)	DME Info	Homo sapiens	[1]
	NADH-ubiquinone oxidoreductase 49 kDa (NDUFS2)	DME Info	Homo sapiens	[1]
	NADH-ubiquinone oxidoreductase 30 kDa (NDUFS3)	DME Info	Homo sapiens	[1]
	Nitric oxide synthase inducible (NOS2)	DME Info	Homo sapiens	[4]
	Nitric oxide synthase endothelial (NOS3)	DME Info	Homo sapiens	[4]
	Phosphorylethanolamine transferase (PCYT2)	DME Info	Homo sapiens	[1]
	Phosphoribosylformylglycinamidine synthase (PFAS)	DME Info	Homo sapiens	[1]
	Superoxide dismutase 1 (SOD1)	DME Info	Homo sapiens	[1]
	Thymidylate synthase (TYMS)	DME Info	Homo sapiens	[1]
	Uracil phosphoribosyltransferase (UPRT)	DME Info	Homo sapiens	[1]
DME(s) Induced by This Xenobiotics
	Adenosine aminohydrolase (ADA)	DME Info	Homo sapiens	[1]
	Aldo-keto reductase 1A1 (AKR1A1)	DME Info	Homo sapiens	[1]
	Aldehyde dehydrogenase 2 (ALDH2)	DME Info	Homo sapiens	[1]
	Adenine phosphoribosyltransferase (APRT)	DME Info	Homo sapiens	[1]
	Aquaporin adipose (AQP7)	DME Info	Homo sapiens	[1]
	Asparagine synthetase (ASNS)	DME Info	Homo sapiens	[1]
	Catalase (CAT)	DME Info	Homo sapiens	[5]
	Cholesterol desmolase (CYP11A1)	DME Info	Homo sapiens	[6]
	Cytochrome P450 1A2 (CYP1A2)	DME Info	Homo sapiens	[7]
	Vitamin D(3) 25-hydroxylase (CYP27A1)	DME Info	Homo sapiens	[1]
	Cytochrome P450 2A6 (CYP2A6)	DME Info	Homo sapiens	[7]
	Cytochrome P450 2B6 (CYP2B6)	DME Info	Homo sapiens	[7]
	Cytochrome P450 2J2 (CYP2J2)	DME Info	Homo sapiens	[1]
	Lauric acid omega-hydroxylase (CYP4A11)	DME Info	Homo sapiens	[1]
	Oleamide hydrolase 1 (FAAH)	DME Info	Homo sapiens	[1]
	Hexosephosphate aminotransferase 2 (GFPT2)	DME Info	Homo sapiens	[1]
	Glutamine amidotransferase (GMPS)	DME Info	Homo sapiens	[1]
	Glutathione reductase (GSR)	DME Info	Homo sapiens	[5]
	N-acetyl-beta-glucosaminidase beta (HEXB)	DME Info	Homo sapiens	[1]
	Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2)	DME Info	Homo sapiens	[8]
	Peroxisomal multifunctional enzyme 2 (HSD17B4)	DME Info	Homo sapiens	[1]
	Monoamine oxidase type A (MAO-A)	DME Info	Homo sapiens	[1]
	Peptide methionine sulfoxide reductase (MSRA)	DME Info	Homo sapiens	[1]
	Metallothionein-1A (MT1A)	DME Info	Homo sapiens	[1]
	Metallothionein-2A (MT2A)	DME Info	Homo sapiens	[1]
	Propionyl-CoA carboxylase beta (PCCB)	DME Info	Homo sapiens	[1]
	NADPH-cytochrome P450 reductase (CPR)	DME Info	Homo sapiens	[1]
	Prostaglandin G/H synthase 1 (COX-1)	DME Info	Homo sapiens	[1]
	Putrescine acetyltransferase (SSAT1)	DME Info	Homo sapiens	[1]
	Transglutaminase Y (TGM6)	DME Info	Homo sapiens	[1]

References
1	Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
2	Cytotoxic effects and aromatase inhibition by xenobiotic endocrine disrupters alone and in combination. Toxicol Appl Pharmacol. 2007 Jul 15;222(2):129-40.
3	An evaluation of the cytochrome P450 inhibition potential of selected pesticides in human hepatic microsomes. J Environ Sci Health B. 2009 Aug;44(6):553-63.
4	Triazine herbicides inhibit relaxin signaling and disrupt nitric oxide homeostasis. Toxicol Appl Pharmacol. 2016 Sep 15;307:10-18.
5	Biflavanone-kolaviron protects human dopaminergic SH-SY5Y cells against atrazine induced toxic insult. Toxicol In Vitro. 2011 Jun;25(4):848-58.
6	A hierarchical testing strategy for micropollutants in drinking water regarding their potential endocrine-disrupting effects-towards health-related indicator values. Environ Sci Pollut Res Int. 2018 Feb;25(5):4051-4065.
7	Characterization of human cytochrome P450 induction by pesticides. Toxicology. 2012 Mar 29;294(1):17-26.
8	The herbicide atrazine activates endocrine gene networks via non-steroidal NR5A nuclear receptors in fish and mammalian cells. PLoS One. 2008 May 7;3(5):e2117.

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