Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01031)
Xenobiotics Name
Tris(1,3-dichloro-2-propyl)phosphate
Xenobiotics Type
Health or Environmental Toxicant(s)
Classification
Health Hazard/Toxicant
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=26177"></iframe>
3D MOL 2D MOL
PubChem CID
26177
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Alcohol dehydrogenase class-II (ADH4) DME Info Homo sapiens [1]
Alcohol dehydrogenase class-V (ADH6) DME Info Homo sapiens [2]
Small intestine reductase (AKR1B10) DME Info Homo sapiens [3]
Aldehyde dehydrogenase 5 (ALDHX) DME Info Homo sapiens [4]
Microsomal cytochrome MCB5 (CYB5A) DME Info Homo sapiens [4]
Retinoic acid 4-hydroxylase 26A1 (CYP26A1) DME Info Homo sapiens [4], [5]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [3]
DOPA decarboxylase (DDC) DME Info Homo sapiens [6]
Delta(24)-sterol reductase (DHCR24) DME Info Homo sapiens [4]
Thymidylate kinase (DTYMK) DME Info Homo sapiens [4]
Fatty acid desaturase 2 (FADS2) DME Info Homo sapiens [4], [5]
Glutamyl-tRNA(Gln) amidotransferase B (GATB) DME Info Homo sapiens [4]
Glutathione S-transferase theta-1 (GSTT1) DME Info Homo sapiens [7]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [4]
Monoamine oxidase type B (MAO-B) DME Info Homo sapiens [8]
Ecto-5'-nucleotidase (NT5E) DME Info Homo sapiens [9]
Sulfotransferase 1A2 (SULT1A2) DME Info Homo sapiens [6]
Sulfotransferase 2B1 (SULT2B1) DME Info Homo sapiens [4]
Thymidylate synthase (TYMS) DME Info Homo sapiens [3]
DME(s) Induced by This Xenobiotics
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [4], [5]
Hydroxyindole O-methyltransferase (ASMT) DME Info Homo sapiens [4]
Asparagine synthetase (ASNS) DME Info Homo sapiens [4], [5]
Serine sulfhydrase (CBS) DME Info Homo sapiens [10]
Cytidine aminohydrolase (CDA) DME Info Homo sapiens [11]
Cholesterol desmolase (CYP11A1) DME Info Homo sapiens [7]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [12]
Vitamin D(3) 24-hydroxylase (CYP24A1) DME Info Homo sapiens [13], [14]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [3], [15]
Cytochrome P450 3A7 (CYP3A7) DME Info Homo sapiens [3]
Glutathione S-transferase omega-2 (GSTO2) DME Info Homo sapiens [4]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info Homo sapiens [3]
Metallothionein-2A (MT2A) DME Info Homo sapiens [7]
NADPH-cytochrome P450 reductase (CPR) DME Info Homo sapiens [2]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [16]
Putrescine acetyltransferase (SSAT1) DME Info Homo sapiens [4]
Uridine phosphorylase 1 (UPP1) DME Info Homo sapiens [4], [5]
References
1 Species-specific differences in the inhibition of human and zebrafish 11beta-hydroxysteroid dehydrogenase 2 by thiram and organotins. Toxicology. 2012 Nov 15;301(1-3):72-8.
2 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
3 Defensive and adverse energy-related molecular responses precede tris (1, 3-dichloro-2-propyl) phosphate cytotoxicity. J Appl Toxicol. 2016 May;36(5):649-58.
4 Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
5 Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
6 Investigation of lymphocyte gene expression for use as biomarkers for zinc status in humans. J Nutr. 2004 Jul;134(7):1716-23.
7 Zinc ferrite nanoparticles activate IL-1b, NFKB1, CCL21 and NOS2 signaling to induce mitochondrial dependent intrinsic apoptotic pathway in WISH cells. Toxicol Appl Pharmacol. 2013 Dec 1;273(2):289-97.
8 Genomic analysis, cytokine expression, and microRNA profiling reveal biomarkers of human dietary zinc depletion and homeostasis. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):20970-5.
9 A global view of the selectivity of zinc deprivation and excess on genes expressed in human THP-1 mononuclear cells. Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6952-7.
10 Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity. Arch Toxicol. 2018 Jan;92(1):469-485.
11 Zinc induces catalase expression in cultured fetal human retinal pigment epithelial cells. Curr Eye Res. 1997 Oct;16(10):1017-23.
12 Zinc deficiency alters DNA damage response genes in normal human prostate epithelial cells. J Nutr. 2008 Apr;138(4):667-73.
13 p38 and EGF receptor kinase-mediated activation of the phosphatidylinositol 3-kinase/Akt pathway is required for Zn2+-induced cyclooxygenase-2 expression. Am J Physiol Lung Cell Mol Physiol. 2005 Nov;289(5):L883-9.
14 Regulation of cyclooxygenase-2 expression by cAMP response element and mRNA stability in a human airway epithelial cell line exposed to zinc. Toxicol Appl Pharmacol. 2008 Sep 1;231(2):260-6.
15 Endocrine disruption potentials of organophosphate flame retardants and related mechanisms in H295R and MVLN cell lines and in zebrafish. Aquat Toxicol. 2012 Jun 15;114-115:173-81.
16 Dose effects of apical versus basolateral zinc supplementation on epithelial resistance, viability, and metallothionein expression in two intestinal epithelial cell lines. J Biochem Mol Toxicol. 2015 Sep;29(9):410-417.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.