Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01154)
Xenobiotics Name
4-oxoretinoic acid
Xenobiotics Type
Natural Product(s), Extract(s) or Medicine(s)
Classification
Natural Product
Structure
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3D MOL 2D MOL
PubChem CID
6437063
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Vitamin D(3) 25-hydroxylase (CYP27A1) DME Info Homo sapiens [1]
Cytochrome P450 3A7 (CYP3A7) DME Info Homo sapiens [1]
Lauric acid omega-hydroxylase (CYP4A11) DME Info Homo sapiens [1]
Glutathione S-transferase mu-1 (GSTM1) DME Info Homo sapiens [1]
Prostaglandin G/H synthase 1 (COX-1) DME Info Homo sapiens [1]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [1]
Sulfotransferase 2A1 (SULT2A1) DME Info Homo sapiens [1]
Transglutaminase K (TGM1) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Retinoic acid 4-hydroxylase 26A1 (CYP26A1) DME Info Homo sapiens [2]
Glutamine synthetase (GLUL) DME Info Homo sapiens [1]
Transglutaminase H (TGM2) DME Info Homo sapiens [3]
References
1 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
2 Induction of CYP26A1 by metabolites of retinoic acid: evidence that CYP26A1 is an important enzyme in the elimination of active retinoids. Mol Pharmacol. 2015;87(3):430-41.
3 Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.

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