Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01247)
Xenobiotics Name
Chloropicrin
Xenobiotics Type
Health or Environmental Toxicant(s)
Classification
Acute Toxic Substance
Structure
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3D MOL 2D MOL
PubChem CID
6423
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cellular glutathione peroxidase (GPX1) DME Info Homo sapiens [1]
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [1]
Adenosine 5'-monophosphoramidase (HINT1) DME Info Homo sapiens [1]
S-adenosylmethionine synthase 2 (MAT2A) DME Info Homo sapiens [1]
Metallothionein-2A (MT2A) DME Info Homo sapiens [1]
Ecto-5'-nucleotidase (NT5E) DME Info Homo sapiens [2]
Phosphoglucomutase 1 (PGM1) DME Info Homo sapiens [1]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Aldo-keto reductase 1C2 (AKR1C2) DME Info Homo sapiens [2]
Aldo-keto reductase 1C4 (AKR1C4) DME Info Homo sapiens [1]
Aldo-keto reductase 1D1 (AKR1D1) DME Info Homo sapiens [1]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [2]
Glutathione S-transferase omega-1 (GSTO1) DME Info Homo sapiens [1]
Keto-steroid reductase (HSD17B7) DME Info Homo sapiens [1]
Monoamine oxidase type A (MAO-A) DME Info Homo sapiens [2]
Metallothionein-1A (MT1A) DME Info Homo sapiens [1]
NADH-ubiquinone oxidoreductase 30 kDa (NDUFS3) DME Info Homo sapiens [1]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [3], [1]
Prostaglandin reductase 1 (PTGR1) DME Info Homo sapiens [1]
Superoxide dismutase 1 (SOD1) DME Info Homo sapiens [1]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [3], [1]
Vitamin K1 2,3-epoxide reductase 1 (VKOR) DME Info Homo sapiens [1]
References
1 Transcriptomic analysis of human primary bronchial epithelial cells after chloropicrin treatment. Chem Res Toxicol. 2015 Oct 19;28(10):1926-35.
2 Molecular targets of chloropicrin in human airway epithelial cells. Toxicol In Vitro. 2017 Aug;42:247-254.
3 Gene expressions changes in bronchial epithelial cells: markers for respiratory sensitizers and exploration of the NRF2 pathway. Toxicol In Vitro. 2014 Mar;28(2):209-17.

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