Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01298)
Xenobiotics Name
Farnesol
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Investigative Agent
Structure
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3D MOL 2D MOL
PubChem CID
3327
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Ampc beta-lactamase (ampC) DME Info Burkholderia cenocepacia [1]
AmpC beta-lactamase (ampC) DME Info Burkholderia multivorans [1]
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [2]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [3]
NADPH-dependent oxidoreductase (nfrA) DME Info Staphylococcus aureus [4]
Beta-lactamase (blaB) DME Info Burkholderia multivorans [1]
Beta-lactamase (blaB) DME Info Burkholderia cenocepacia [1]
DME(s) Induced by This Xenobiotics
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [5]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [5]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [2]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [2]
References
1 Use of quorum sensing inhibitors to interfere with biofilm formation and development in Burkholderia multivorans and Burkholderia cenocepacia. Res Microbiol. 2009 Mar;160(2):144-51.
2 Farnesol induces fatty acid oxidation and decreases triglyceride accumulation in steatotic HepaRG cells. Toxicol Appl Pharmacol. 2019 Feb 15;365:61-70.
3 Regulation of isoprenoid/cholesterol biosynthesis in cells from mevalonate kinase-deficient patients. J Biol Chem. 2003 Feb 21;278(8):5736-43.
4 Effect of farnesol on Staphylococcus aureus biofilm formation and antimicrobial susceptibility. Antimicrob Agents Chemother. 2006 Apr;50(4):1463-9.
5 The THP-1 cell toolbox: a new concept integrating the key events of skin sensitization. Arch Toxicol. 2019 Apr;93(4):941-951.

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