Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME2100)
DME Name Beta-lactamase (blaB), Burkholderia multivorans
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; Beta-lactamase TEM; IRT-4; TEM-1
Gene Name penA
UniProt ID
PENA_BURM1
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Burkholderia multivorans     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Burkholderiales
Family: Burkholderiaceae
Genus: Burkholderia
Species: Burkholderia multivorans
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human lung.
Sequence
MQRIGVTDYTILGTVKGAELELVRFTHPFMGFDVPAILGDHVTRMPVPVPFTPRLPRPGR
LCDRSEIRPGKPLTRLARTALICRALIRRWMARTSYSDSVNCHTQPISAIFDYKDLRFEP
PSNRISPAGQTSVDRLLQLSQGQAVEGQSAVARLTGEKKNHPGAQYANRLSPRIANNHPA
TQQTLFELGSGAKERNAINVSYLTALGTPGFTLMLPARMLCGIVSDNNFTQKQLCPSPAR
CTRGPAEPAKRGPWLEPGLVIRKDGLRTGKLLSSLRGLCLTVLRFQPTVPCFCRLALSSS
VAISSTGLVNFSR
Function This enzyme hydrolyzes beta-lactam with a substrate specificity for penicillin.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Cefotaxime
 Drug Info Approved Meningitis ICD11: 1A62 [1]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Cefaloridine
 Drug Info Phase 4 Staphylococcus infection ICD11: 1B73 [2]
References
1 Overcoming an extremely drug resistant (XDR) pathogen: avibactam restores susceptibility to ceftazidime for Burkholderia cepacia complex isolates from cystic fibrosis patients. ACS Infect Dis. 2017 Jul 14;3(7):502-511.
2 Characterization of the penA and penR genes of Burkholderia cepacia 249 which encode the chromosomal class A penicillinase and its LysR-type transcriptional regulator. Antimicrob Agents Chemother. 1997 Nov;41(11):2399-405.

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