Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01302)
Xenobiotics Name
Fipronil
Xenobiotics Type
Health or Environmental Toxicant(s)
Classification
Acute Toxic Substance
Structure
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3D MOL 2D MOL
PubChem CID
3352
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Alcohol dehydrogenase class-I beta (ADH1B) DME Info Homo sapiens [1]
Cytochrome P450 2D6 (CYP2D6) DME Info Homo sapiens [2]
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [1]
Lauric acid omega-hydroxylase (CYP4A11) DME Info Homo sapiens [1]
Testicular 17-beta-hydroxysteroid dehydrogenase (HSD17B3) DME Info Homo sapiens [1]
Dihydrotestosterone oxidoreductase (HSD3B1) DME Info Homo sapiens [1]
Sulfotransferase 1B1 (SULT1B1) DME Info Homo sapiens [1]
Sulfotransferase 1E1 (SULT1E1) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Microsomal cytochrome MCB5 (CYB5A) DME Info Homo sapiens [1]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [3], [1]
Steroid 21-hydroxylase (CYP21A2) DME Info Homo sapiens [1]
Retinoic acid 4-hydroxylase 26A1 (CYP26A1) DME Info Homo sapiens [1]
Retinoic acid 4-hydroxylase 26B1 (CYP26B1) DME Info Homo sapiens [1]
Cytochrome P450 2A6 (CYP2A6) DME Info Homo sapiens [1]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [3], [1]
Cytochrome P450 2C8 (CYP2C8) DME Info Homo sapiens [1]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [1]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [3]
Cytochrome P450 3A43 (CYP3A43) DME Info Homo sapiens [1]
Cytochrome P450 3A5 (CYP3A5) DME Info Homo sapiens [3], [1]
Cytochrome P450 3A7 (CYP3A7) DME Info Homo sapiens [1]
Keto-steroid reductase (HSD17B7) DME Info Homo sapiens [1]
NADPH-cytochrome P450 reductase (CPR) DME Info Homo sapiens [1]
References
1 Impact of environmental chemicals on the transcriptome of primary human hepatocytes: potential for health effects. J Biochem Mol Toxicol. 2016 Aug;30(8):375-95.
2 In vitro inhibition of human CYP2D6 by the chiral pesticide fipronil and its metabolite fipronil sulfone: prediction of pesticide-drug interactions. Toxicol Lett. 2019 Oct 1;313:196-204.
3 Fipronil induces CYP isoforms and cytotoxicity in human hepatocytes. Chem Biol Interact. 2006 Dec 15;164(3):200-14.

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