Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01585)
Xenobiotics Name
Senecionine
Xenobiotics Type
Natural Product(s), Extract(s) or Medicine(s)
Classification
Natural Product
Structure
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3D MOL 2D MOL
PubChem CID
5280906
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Bile acid-CoA thioesterase (BAAT) DME Info Homo sapiens [1]
Cytochrome P450 2C18 (CYP2C18) DME Info Homo sapiens [2]
Lauric acid omega-hydroxylase (CYP4A11) DME Info Homo sapiens [3]
Cytochrome P450 4F12 (CYP4F12) DME Info Homo sapiens [1]
Bifunctional epoxide hydrolase 2 (EPHX2) DME Info Homo sapiens [4]
Glutathione S-transferase theta-1 (GSTT1) DME Info Homo sapiens [5]
Histamine N-methyltransferase (HNMT) DME Info Homo sapiens [1]
Kynurenine aminotransferase I (KYAT1) DME Info Homo sapiens [1]
UDP-glucuronosyltransferase 2A3 (UGT2A3) DME Info Homo sapiens [4]
DME(s) Induced by This Xenobiotics
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [6]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [2]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [2]
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [7]
Cytochrome P450 3A43 (CYP3A43) DME Info Homo sapiens [2]
Cytochrome P450 3A7 (CYP3A7) DME Info Homo sapiens [2]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [1]
Thiopurine methyltransferase (TPMT) DME Info Homo sapiens [6], [7]
References
1 ETS2 regulating neurodegenerative signaling pathway of human neuronal (SH-SY5Y) cells exposed to single and repeated low-dose sarin (GB). Chem Res Toxicol. 2009 Jun;22(6):990-6.
2 Sanguinarine activates polycyclic aromatic hydrocarbon associated metabolic pathways in human oral keratinocytes and tissues. Toxicol Lett. 2005 Jul 28;158(1):50-60.
3 High-throughput library screening identifies two novel NQO1 inducers in human lung cells. Am J Respir Cell Mol Biol. 2012 Mar;46(3):365-71.
4 Selective inhibition of cytochrome P450 2D6 by Sarpogrelate and its active metabolite, M-1, in human liver microsomes. Drug Metab Dispos. 2014 Jan;42(1):33-9.
5 Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry. Toxicol Sci. 2007 Nov;100(1):136-45.
6 Role for the PI3K/Akt/Nrf2 signaling pathway in the protective effects of carnosic acid against methylglyoxal-induced neurotoxicity in SH-SY5Y neuroblastoma cells. Chem Biol Interact. 2015 Dec 5;242:396-406.
7 Protective effect of carnosic acid against paraquat-induced redox impairment and mitochondrial dysfunction in SH-SY5Y cells: Role for PI3K/Akt/Nrf2 pathway. Toxicol In Vitro. 2016 Apr;32:41-54.

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