Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1023)
DME Name Beta-lactamase (blaB), Klebsiella pneumoniae DME Info
UniProt ID
A0A378EHS6_KLEPR
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Klebsiella pneumoniae     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Klebsiella
Species: Klebsiella pneumoniae
Subspecies: Klebsiella pneumoniae subsp. Rhinoscleromatis
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Aztreonam Click to Show/Hide the Full List of HOSPPI:        3 HOSPPI
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-blaB interaction [1], [2]
Description The interaction, between human Cytochrome P450 3A4 and Beta-lactamase from Klebsiella pneumoniae which collectively metabolize the drug Aztreonam, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A5 (CYP3A5) Click to Show/Hide the Cometabolization Info
DME ID DME0012 DME Info
Uniprot ID
CP3A5_HUMAN
Interaction Name CYP3A5-blaB interaction [1], [2]
Description The interaction, between human Cytochrome P450 3A5 and Beta-lactamase from Klebsiella pneumoniae which collectively metabolize the drug Aztreonam, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A7 (CYP3A7) Click to Show/Hide the Cometabolization Info
DME ID DME0015 DME Info
Uniprot ID
CP3A7_HUMAN
Interaction Name CYP3A7-blaB interaction [1], [2]
Description The interaction, between human Cytochrome P450 3A7 and Beta-lactamase from Klebsiella pneumoniae which collectively metabolize the drug Aztreonam, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: Cefazolin Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Thiopurine methyltransferase (TPMT) Click to Show/Hide the Cometabolization Info
DME ID DME0014 DME Info
Uniprot ID
TPMT_HUMAN
Interaction Name TPMT-blaB interaction [1], [3]
Description The interaction, between human Thiopurine methyltransferase and Beta-lactamase from Klebsiella pneumoniae which collectively metabolize the drug Cefazolin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Analysis of the drug-resistant characteristics of Klebsiella pneumoniae isolated from the respiratory tract and CTX-M ESBL genes. Genet Mol Res. 2015 Oct 5;14(4):12043-8.
2 Aztreonam decreases hepatic microsomal cytochrome P450 in cynomolgus monkeys. Pharmacology. 1994 Mar;48(3):137-42.
3 Cefazolin administration and 2-methyl-1,3,4-thiadiazole-5-thiol in human tissue: possible relationship to hypoprothrombinemia. Drug Metab Dispos. 2002 Oct;30(10):1123-8.

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