Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1037)
DME Name Dopamine dehydroxylase (dadH), Eggerthella lenta DME Info
UniProt ID
DADH_EGGLN
EC Number    EC: 1.1.1.-     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.-
Lineage    Species: Eggerthella lenta     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Coriobacteriia
Order: Eggerthellales
Family: Eggerthellaceae
Genus: Eggerthella
Species: Eggerthella lenta
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Dopamine hydrochloride Click to Show/Hide the Full List of HOSPPI:        7 HOSPPI
                            Catechol O-methyltransferase (COMT) Click to Show/Hide the Cometabolization Info
DME ID DME0043 DME Info
Uniprot ID
COMT_HUMAN
Interaction Name COMT-dadH interaction [1], [2]
Description The interaction, between human Catechol O-methyltransferase and Dopamine dehydroxylase from Eggerthella lenta which collectively metabolize the drug Dopamine hydrochloride, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 1A2 (CYP1A2) Click to Show/Hide the Cometabolization Info
DME ID DME0003 DME Info
Uniprot ID
CP1A2_HUMAN
Interaction Name CYP1A2-dadH interaction [1], [3]
Description The interaction, between human Cytochrome P450 1A2 and Dopamine dehydroxylase from Eggerthella lenta which collectively metabolize the drug Dopamine hydrochloride, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2C9 (CYP2C9) Click to Show/Hide the Cometabolization Info
DME ID DME0019 DME Info
Uniprot ID
CP2C9_HUMAN
Interaction Name CYP2C9-dadH interaction [1], [4]
Description The interaction, between human Cytochrome P450 2C9 and Dopamine dehydroxylase from Eggerthella lenta which collectively metabolize the drug Dopamine hydrochloride, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2D6 (CYP2D6) Click to Show/Hide the Cometabolization Info
DME ID DME0009 DME Info
Uniprot ID
CP2D6_HUMAN
Interaction Name CYP2D6-dadH interaction [1], [4]
Description The interaction, between human Cytochrome P450 2D6 and Dopamine dehydroxylase from Eggerthella lenta which collectively metabolize the drug Dopamine hydrochloride, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Mephenytoin 4-hydroxylase (CYP2C19) Click to Show/Hide the Cometabolization Info
DME ID DME0021 DME Info
Uniprot ID
CP2CJ_HUMAN
Interaction Name CYP2C19-dadH interaction [1], [4]
Description The interaction, between human Mephenytoin 4-hydroxylase and Dopamine dehydroxylase from Eggerthella lenta which collectively metabolize the drug Dopamine hydrochloride, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Monoamine oxidase type B (MAO-B) Click to Show/Hide the Cometabolization Info
DME ID DME0045 DME Info
Uniprot ID
AOFB_HUMAN
Interaction Name MAO-B-dadH interaction [1], [5]
Description The interaction, between human Monoamine oxidase type B and Dopamine dehydroxylase from Eggerthella lenta which collectively metabolize the drug Dopamine hydrochloride, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Sulfotransferase 1B1 (SULT1B1) Click to Show/Hide the Cometabolization Info
DME ID DME0380 DME Info
Uniprot ID
ST1B1_HUMAN
Interaction Name SULT1B1-dadH interaction [1], [6]
Description The interaction, between human Sulfotransferase 1B1 and Dopamine dehydroxylase from Eggerthella lenta which collectively metabolize the drug Dopamine hydrochloride, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism. Science. 2019 Jun 14;364(6445). pii: eaau6323.
2 Association between polymorphisms in catechol-O-methyltransferase (COMT) and cocaine-induced paranoia in European-American and African-American populations. Am J Med Genet B Neuropsychiatr Genet. 2011 Sep;156B(6):651-60.
3 Modulation of CYP1A2 enzyme activity by indoleamines: inhibition by serotonin and tryptamine. Pharmacogenetics. 1998 Jun;8(3):251-8.
4 Pharmacogenetics of schizophrenia. Am J Med Genet. 2000 Spring;97(1):98-106.
5 Monoamine oxidases (MAO) in the pathogenesis of heart failure and ischemia/reperfusion injury. Biochim Biophys Acta. 2011 Jul;1813(7):1323-32.
6 Molecular cloning, expression, and functional characterization of novel mouse sulfotransferases. Biochem Biophys Res Commun. 1998 Jun 29;247(3):681-6.

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