Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1063)
DME Name Nitroreductase (NTR), Salmonella enterica DME Info
UniProt ID
A0A5K1UB29_SALTM
EC Number    EC: 1.5.1.39     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.39
Lineage    Species: Salmonella enterica     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Salmonella
Species: Salmonella enterica
Subspecies: Salmonella enterica subsp. enterica serovar Typhimurium
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Menadione Click to Show/Hide the Full List of HOSPPI:        9 HOSPPI
                            Cytochrome P450 1A1 (CYP1A1) Click to Show/Hide the Cometabolization Info
DME ID DME0006 DME Info
Uniprot ID
CP1A1_HUMAN
Interaction Name CYP1A1-NTR interaction [1], [2], [3]
Description The interaction, between human Cytochrome P450 1A1 and Nitroreductase from Salmonella enterica which collectively metabolize the drug Menadione, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 1A2 (CYP1A2) Click to Show/Hide the Cometabolization Info
DME ID DME0003 DME Info
Uniprot ID
CP1A2_HUMAN
Interaction Name CYP1A2-NTR interaction [1], [2], [3]
Description The interaction, between human Cytochrome P450 1A2 and Nitroreductase from Salmonella enterica which collectively metabolize the drug Menadione, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2E1 (CYP2E1) Click to Show/Hide the Cometabolization Info
DME ID DME0013 DME Info
Uniprot ID
CP2E1_HUMAN
Interaction Name CYP2E1-NTR interaction [1], [2], [4]
Description The interaction, between human Cytochrome P450 2E1 and Nitroreductase from Salmonella enterica which collectively metabolize the drug Menadione, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Methionine synthase reductase (MTRR) Click to Show/Hide the Cometabolization Info
DME ID DME0431 DME Info
Uniprot ID
MTRR_HUMAN
Interaction Name MTRR-NTR interaction [1], [2], [5]
Description The interaction, between human Methionine synthase reductase and Nitroreductase from Salmonella enterica which collectively metabolize the drug Menadione, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Methylenetetrahydrofolate reductase (MTHFR) Click to Show/Hide the Cometabolization Info
DME ID DME0083 DME Info
Uniprot ID
MTHR_HUMAN
Interaction Name MTHFR-NTR interaction [1], [2], [6]
Description The interaction, between human Methylenetetrahydrofolate reductase and Nitroreductase from Salmonella enterica which collectively metabolize the drug Menadione, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            NADPH-dependent carbonyl reductase 1 (CBR1) Click to Show/Hide the Cometabolization Info
DME ID DME0067 DME Info
Uniprot ID
CBR1_HUMAN
Interaction Name CBR1-NTR interaction [1], [2], [7]
Description The interaction, between human NADPH-dependent carbonyl reductase 1 and Nitroreductase from Salmonella enterica which collectively metabolize the drug Menadione, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            NADPH-dependent carbonyl reductase 3 (CBR3) Click to Show/Hide the Cometabolization Info
DME ID DME0068 DME Info
Uniprot ID
CBR3_HUMAN
Interaction Name CBR3-NTR interaction [1], [2], [8]
Description The interaction, between human NADPH-dependent carbonyl reductase 3 and Nitroreductase from Salmonella enterica which collectively metabolize the drug Menadione, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            NADPH:quinone reductase (CRYZ) Click to Show/Hide the Cometabolization Info
DME ID DME0468 DME Info
Uniprot ID
QOR_HUMAN
Interaction Name CRYZ-NTR interaction [1], [2], [9]
Description The interaction, between human NADPH:quinone reductase and Nitroreductase from Salmonella enterica which collectively metabolize the drug Menadione, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Sepiapterin reductase (SPR) Click to Show/Hide the Cometabolization Info
DME ID DME0570 DME Info
Uniprot ID
SPRE_HUMAN
Interaction Name SPR-NTR interaction [1], [2], [10]
Description The interaction, between human Sepiapterin reductase and Nitroreductase from Salmonella enterica which collectively metabolize the drug Menadione, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Purification and characterization of wild-type and mutant "classical" nitroreductases of Salmonella typhimurium. L33R mutation greatly diminishes binding of FMN to the nitroreductase of S. typhimurium. J Biol Chem. 1998 Sep 11;273(37):23922-8.
2 Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27.
3 Rat hepatic CYP1A1 and CYP1A2 induction by menadione. Toxicol Lett. 2005 Feb 15;155(2):253-8.
4 CYP2E1 overexpression alters hepatocyte death from menadione and fatty acids by activation of ERK1/2 signaling. Hepatology. 2004 Feb;39(2):444-55.
5 Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase. Biochemistry. 2002 Nov 12;41(45):13378-85.
6 Purification and properties of 5,10-methylenetetrahydrofolate reductase, an iron-sulfur flavoprotein from Clostridium formicoaceticum. J Biol Chem. 1984 Sep 10;259(17):10845-9.
7 Polycyclic aromatic hydrocarbon quinones and glutathione thioethers as substrates and inhibitors of the human placental NADP-linked 15-hydroxyprostaglandin dehydrogenase. J Biol Chem. 1987 Sep 15;262(26):12448-51.
8 Different functions between human monomeric carbonyl reductase 3 and carbonyl reductase 1. Mol Cell Biochem. 2008 Aug;315(1-2):113-21.
9 Role of glutathione reductase during menadione-induced NADPH oxidation in isolated rat hepatocytes. Biochem Pharmacol. 1987 Nov 15;36(22):3879-84.
10 Sepiapterin reductase mediates chemical redox cycling in lung epithelial cells. J Biol Chem. 2013 Jun 28;288(26):19221-37.

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