Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1234)
DME Name Cytochrome P450 124 (cyp124), Mycobacterium tuberculosis DME Info
UniProt ID
CP124_MYCTU
EC Number    EC: 1.14.15.14     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Iron-sulfur protein donor oxidoreductase
EC: 1.14.15.14
Lineage    Species: Mycobacterium tuberculosis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Corynebacteriales
Family: Mycobacteriaceae
Genus: Mycobacterium
Species: Mycobacterium tuberculosis
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Vitamin D Click to Show/Hide the Full List of HOSPPI:        5 HOSPPI
                            Cholesterol desmolase (CYP11A1) Click to Show/Hide the Cometabolization Info
DME ID DME0099 DME Info
Uniprot ID
CP11A_HUMAN
Interaction Name CYP11A1-cyp124 interaction [1], [2]
Description The interaction, between human Cholesterol desmolase and Cytochrome P450 124 from Mycobacterium tuberculosis which collectively metabolize the drug Vitamin D, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2J2 (CYP2J2) Click to Show/Hide the Cometabolization Info
DME ID DME0031 DME Info
Uniprot ID
CP2J2_HUMAN
Interaction Name CYP2J2-cyp124 interaction [1], [3]
Description The interaction, between human Cytochrome P450 2J2 and Cytochrome P450 124 from Mycobacterium tuberculosis which collectively metabolize the drug Vitamin D, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-cyp124 interaction [1], [4]
Description The interaction, between human Cytochrome P450 3A4 and Cytochrome P450 124 from Mycobacterium tuberculosis which collectively metabolize the drug Vitamin D, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Vitamin D 25-hydroxylase (CYP2R1) Click to Show/Hide the Cometabolization Info
DME ID DME0100 DME Info
Uniprot ID
CP2R1_HUMAN
Interaction Name CYP2R1-cyp124 interaction [1], [5]
Description The interaction, between human Vitamin D 25-hydroxylase and Cytochrome P450 124 from Mycobacterium tuberculosis which collectively metabolize the drug Vitamin D, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Vitamin D(3) 25-hydroxylase (CYP27A1) Click to Show/Hide the Cometabolization Info
DME ID DME0026 DME Info
Uniprot ID
CP27A_HUMAN
Interaction Name CYP27A1-cyp124 interaction [1], [6]
Description The interaction, between human Vitamin D(3 25-hydroxylase and Cytochrome P450 124 from Mycobacterium tuberculosis which collectively metabolize the drug Vitamin D, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Identification of Mycobacterium tuberculosis enzyme involved in vitamin D and 7-dehydrocholesterol metabolism. J Steroid Biochem Mol Biol. 2017 May;169:202-209.
2 Metabolism of 1alpha-hydroxyvitamin D3 by cytochrome P450scc to biologically active 1alpha,20-dihydroxyvitamin D3. J Steroid Biochem Mol Biol. 2008 Dec;112(4-5):213-9.
3 Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylases. Steroids. 2006 Oct;71(10):849-56.
4 Interplay between vitamin D and the drug metabolizing enzyme CYP3A4. J Steroid Biochem Mol Biol. 2013 Jul;136:54-8.
5 Placental vitamin D metabolism and its associations with circulating vitamin D metabolites in pregnant women. Am J Clin Nutr. 2017 Dec;106(6):1439-1448.
6 Chemoprevention of prostate cancer by cholecalciferol (vitamin D3): 25-hydroxylase (CYP27A1) in human prostate epithelial cells. Clin Exp Metastasis. 2005;22(3):265-73.

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