Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1472)
DME Name Cytochrome P450 21A2 (cyp21), Bacillus megaterium DME Info
UniProt ID
A0A250VKS1_STROL
EC Number    EC: 1.14.14.16     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.16
Lineage    Species: Bacillus megaterium     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Bacillales
Family: Bacillaceae
Genus: Bacillus
Species: Bacillus megaterium
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Progesterone Click to Show/Hide the Full List of HOSPPI:      15 HOSPPI
                            Aldo-keto reductase 1C1 (AKR1C1) Click to Show/Hide the Cometabolization Info
DME ID DME0197 DME Info
Uniprot ID
AK1C1_HUMAN
Interaction Name AKR1C1-cyp21 interaction [1], [2], [3]
Description The interaction, between human Aldo-keto reductase 1C1 and Cytochrome P450 21A2 from Bacillus megaterium which collectively metabolize the drug Progesterone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cholesterol 24-hydroxylase (CYP46A1) Click to Show/Hide the Cometabolization Info
DME ID DME0028 DME Info
Uniprot ID
CP46A_HUMAN
Interaction Name CYP46A1-cyp21 interaction [1], [2], [4]
Description The interaction, between human Cholesterol 24-hydroxylase and Cytochrome P450 21A2 from Bacillus megaterium which collectively metabolize the drug Progesterone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 1A1 (CYP1A1) Click to Show/Hide the Cometabolization Info
DME ID DME0006 DME Info
Uniprot ID
CP1A1_HUMAN
Interaction Name CYP1A1-cyp21 interaction [1], [2], [5]
Description The interaction, between human Cytochrome P450 1A1 and Cytochrome P450 21A2 from Bacillus megaterium which collectively metabolize the drug Progesterone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 1B1 (CYP1B1) Click to Show/Hide the Cometabolization Info
DME ID DME0023 DME Info
Uniprot ID
CP1B1_HUMAN
Interaction Name CYP1B1-cyp21 interaction [1], [2], [6]
Description The interaction, between human Cytochrome P450 1B1 and Cytochrome P450 21A2 from Bacillus megaterium which collectively metabolize the drug Progesterone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2A6 (CYP2A6) Click to Show/Hide the Cometabolization Info
DME ID DME0005 DME Info
Uniprot ID
CP2A6_HUMAN
Interaction Name CYP2A6-cyp21 interaction [1], [2], [7]
Description The interaction, between human Cytochrome P450 2A6 and Cytochrome P450 21A2 from Bacillus megaterium which collectively metabolize the drug Progesterone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2C9 (CYP2C9) Click to Show/Hide the Cometabolization Info
DME ID DME0019 DME Info
Uniprot ID
CP2C9_HUMAN
Interaction Name CYP2C9-cyp21 interaction [1], [2], [8]
Description The interaction, between human Cytochrome P450 2C9 and Cytochrome P450 21A2 from Bacillus megaterium which collectively metabolize the drug Progesterone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2D6 (CYP2D6) Click to Show/Hide the Cometabolization Info
DME ID DME0009 DME Info
Uniprot ID
CP2D6_HUMAN
Interaction Name CYP2D6-cyp21 interaction [1], [2], [9]
Description The interaction, between human Cytochrome P450 2D6 and Cytochrome P450 21A2 from Bacillus megaterium which collectively metabolize the drug Progesterone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-cyp21 interaction [1], [2], [10]
Description The interaction, between human Cytochrome P450 3A4 and Cytochrome P450 21A2 from Bacillus megaterium which collectively metabolize the drug Progesterone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A5 (CYP3A5) Click to Show/Hide the Cometabolization Info
DME ID DME0012 DME Info
Uniprot ID
CP3A5_HUMAN
Interaction Name CYP3A5-cyp21 interaction [1], [2], [11]
Description The interaction, between human Cytochrome P450 3A5 and Cytochrome P450 21A2 from Bacillus megaterium which collectively metabolize the drug Progesterone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A7 (CYP3A7) Click to Show/Hide the Cometabolization Info
DME ID DME0015 DME Info
Uniprot ID
CP3A7_HUMAN
Interaction Name CYP3A7-cyp21 interaction [1], [2], [12]
Description The interaction, between human Cytochrome P450 3A7 and Cytochrome P450 21A2 from Bacillus megaterium which collectively metabolize the drug Progesterone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 4B1 (CYP4B1) Click to Show/Hide the Cometabolization Info
DME ID DME0010 DME Info
Uniprot ID
CP4B1_HUMAN
Interaction Name CYP4B1-cyp21 interaction [1], [2], [13]
Description The interaction, between human Cytochrome P450 4B1 and Cytochrome P450 21A2 from Bacillus megaterium which collectively metabolize the drug Progesterone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Glutathione S-transferase alpha-1 (GSTA1) Click to Show/Hide the Cometabolization Info
DME ID DME0011 DME Info
Uniprot ID
GSTA1_HUMAN
Interaction Name GSTA1-cyp21 interaction [1], [2], [14]
Description The interaction, between human Glutathione S-transferase alpha-1 and Cytochrome P450 21A2 from Bacillus megaterium which collectively metabolize the drug Progesterone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Mephenytoin 4-hydroxylase (CYP2C19) Click to Show/Hide the Cometabolization Info
DME ID DME0021 DME Info
Uniprot ID
CP2CJ_HUMAN
Interaction Name CYP2C19-cyp21 interaction [1], [2], [8]
Description The interaction, between human Mephenytoin 4-hydroxylase and Cytochrome P450 21A2 from Bacillus megaterium which collectively metabolize the drug Progesterone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Steroid 21-hydroxylase (CYP21A2) Click to Show/Hide the Cometabolization Info
DME ID DME0037 DME Info
Uniprot ID
CP21A_HUMAN
Interaction Name CYP21A2-cyp21 interaction [1], [2], [15]
Description The interaction, between human Steroid 21-hydroxylase and Cytochrome P450 21A2 from Bacillus megaterium which collectively metabolize the drug Progesterone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Sulfotransferase 1A1 (SULT1A1) Click to Show/Hide the Cometabolization Info
DME ID DME0008 DME Info
Uniprot ID
ST1A1_HUMAN
Interaction Name SULT1A1-cyp21 interaction [1], [2], [16]
Description The interaction, between human Sulfotransferase 1A1 and Cytochrome P450 21A2 from Bacillus megaterium which collectively metabolize the drug Progesterone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 acillus megaterium SF185 spores exert protective effects against oxidative stress in vivo and in vitro. Sci Rep. 2019 Aug 19;9(1):12082.
2 A Novel NADPH-dependent flavoprotein reductase from Bacillus megaterium acts as an efficient cytochrome P450 reductase. J Biotechnol. 2016 Aug 10;231:83-94.
3 Human 3-alpha hydroxysteroid dehydrogenase type 3 (3alpha-HSD3): the V54L mutation restricting the steroid alternative binding and enhancing the 20alpha-HSD activity. J Steroid Biochem Mol Biol. 2014 May;141:135-43.
4 Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain. Biochemistry. 2003 Dec 9;42(48):14284-92.
5 Allelic variants of human cytochrome P450 1A1 (CYP1A1): effect of T461N and I462V substitutions on steroid hydroxylase specificity. Pharmacogenetics. 2000 Aug;10(6):519-30.
6 Catalytic properties of polymorphic human cytochrome P450 1B1 variants. Carcinogenesis. 1999 Aug;20(8):1607-13.
7 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
8 Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys. 1997 Oct 1;346(1):161-9.
9 Effect of genetic polymorphism on the metabolism of endogenous neuroactive substances, progesterone and p-tyramine, catalyzed by CYP2D6. Brain Res Mol Brain Res. 2004 Oct 22;129(1-2):117-23.
10 Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones. Xenobiotica. 1998 Jun;28(6):539-47.
11 Human prostate CYP3A5: identification of a unique 5'-untranslated sequence and characterization of purified recombinant protein. Biochem Biophys Res Commun. 1999 Jul 14;260(3):676-81.
12 The role of cytochrome P450 3A (CYP3A) isoform(s) in oxidative metabolism of testosterone and benzphetamine in human adult and fetal liver. J Steroid Biochem Mol Biol. 1993 Jan;44(1):61-7.
13 Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s. Arch Biochem Biophys. 1991 Oct;290(1):160-6.
14 Human glutathione transferase A3-3, a highly efficient catalyst of double-bond isomerization in the biosynthetic pathway of steroid hormones. J Biol Chem. 2001 Aug 31;276(35):33061-5.
15 Human cytochrome P450 21A2, the major steroid 21-hydroxylase: structure of the enzyme progesterone substrate complex and rate-limiting C-H bond cleavage. J Biol Chem. 2015 May 22;290(21):13128-43.
16 Progestagenic effects of tibolone are target gene-specific in human endometrial cells. J Soc Gynecol Investig. 2006 Sep;13(6):459-65.

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