Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1906)
DME Name Alcohol dehydrogenase (ADH), Neisseria sicca DME Info
UniProt ID
A0A2I1XAT4_NEISI
EC Number    EC: 1.1.1.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.1
Lineage    Species: Neisseria sicca     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Neisseriales
Family: Neisseriaceae
Genus: Neisseria
Species: Neisseria sicca
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Ethanol Click to Show/Hide the Full List of HOSPPI:      12 HOSPPI
                            Alcohol dehydrogenase class-I alpha (ADH1A) Click to Show/Hide the Cometabolization Info
DME ID DME0127 DME Info
Uniprot ID
ADH1A_HUMAN
Interaction Name ADH1A-ADH interaction [1], [2]
Description The interaction, between human Alcohol dehydrogenase class-I alpha and Alcohol dehydrogenase from Neisseria sicca which collectively metabolize the drug Ethanol, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Alcohol dehydrogenase class-I beta (ADH1B) Click to Show/Hide the Cometabolization Info
DME ID DME0128 DME Info
Uniprot ID
ADH1B_HUMAN
Interaction Name ADH1B-ADH interaction [1], [2]
Description The interaction, between human Alcohol dehydrogenase class-I beta and Alcohol dehydrogenase from Neisseria sicca which collectively metabolize the drug Ethanol, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Alcohol dehydrogenase class-I gamma (ADH1C) Click to Show/Hide the Cometabolization Info
DME ID DME0129 DME Info
Uniprot ID
ADH1G_HUMAN
Interaction Name ADH1C-ADH interaction [1], [2]
Description The interaction, between human Alcohol dehydrogenase class-I gamma and Alcohol dehydrogenase from Neisseria sicca which collectively metabolize the drug Ethanol, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Alcohol dehydrogenase class-II (ADH4) Click to Show/Hide the Cometabolization Info
DME ID DME0130 DME Info
Uniprot ID
ADH4_HUMAN
Interaction Name ADH4-ADH interaction [1], [3]
Description The interaction, between human Alcohol dehydrogenase class-II and Alcohol dehydrogenase from Neisseria sicca which collectively metabolize the drug Ethanol, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Alcohol dehydrogenase class-III (ADH5) Click to Show/Hide the Cometabolization Info
DME ID DME0132 DME Info
Uniprot ID
ADHX_HUMAN
Interaction Name ADH5-ADH interaction [1], [4]
Description The interaction, between human Alcohol dehydrogenase class-III and Alcohol dehydrogenase from Neisseria sicca which collectively metabolize the drug Ethanol, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Alcohol dehydrogenase class-V (ADH6) Click to Show/Hide the Cometabolization Info
DME ID DME0073 DME Info
Uniprot ID
ADH6_HUMAN
Interaction Name ADH6-ADH interaction [1], [4]
Description The interaction, between human Alcohol dehydrogenase class-V and Alcohol dehydrogenase from Neisseria sicca which collectively metabolize the drug Ethanol, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Aldo-keto reductase 1A1 (AKR1A1) Click to Show/Hide the Cometabolization Info
DME ID DME0098 DME Info
Uniprot ID
AK1A1_HUMAN
Interaction Name AKR1A1-ADH interaction [1], [4]
Description The interaction, between human Aldo-keto reductase 1A1 and Alcohol dehydrogenase from Neisseria sicca which collectively metabolize the drug Ethanol, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 1A2 (CYP1A2) Click to Show/Hide the Cometabolization Info
DME ID DME0003 DME Info
Uniprot ID
CP1A2_HUMAN
Interaction Name CYP1A2-ADH interaction [1], [5]
Description The interaction, between human Cytochrome P450 1A2 and Alcohol dehydrogenase from Neisseria sicca which collectively metabolize the drug Ethanol, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2E1 (CYP2E1) Click to Show/Hide the Cometabolization Info
DME ID DME0013 DME Info
Uniprot ID
CP2E1_HUMAN
Interaction Name CYP2E1-ADH interaction [1], [6]
Description The interaction, between human Cytochrome P450 2E1 and Alcohol dehydrogenase from Neisseria sicca which collectively metabolize the drug Ethanol, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-ADH interaction [1], [5]
Description The interaction, between human Cytochrome P450 3A4 and Alcohol dehydrogenase from Neisseria sicca which collectively metabolize the drug Ethanol, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Gastric alcohol dehydrogenase (ADH7) Click to Show/Hide the Cometabolization Info
DME ID DME0131 DME Info
Uniprot ID
ADH7_HUMAN
Interaction Name ADH7-ADH interaction [1], [4]
Description The interaction, between human Gastric alcohol dehydrogenase and Alcohol dehydrogenase from Neisseria sicca which collectively metabolize the drug Ethanol, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            UDP-glucuronosyltransferase 1A1 (UGT1A1) Click to Show/Hide the Cometabolization Info
DME ID DME0004 DME Info
Uniprot ID
UD11_HUMAN
Interaction Name UGT1A1-ADH interaction [1], [7]
Description The interaction, between human UDP-glucuronosyltransferase 1A1 and Alcohol dehydrogenase from Neisseria sicca which collectively metabolize the drug Ethanol, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Functional profiles of coronal and dentin caries in children. J Oral Microbiol. 2018 Jul 16;10(1):1495976.
2 Natural alcohol exposure: is ethanol the main substrate for alcohol dehydrogenases in animals? Chem Biol Interact. 2011 May 30;191(1-3):14-25.
3 Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases. Toxicology. 2008 Mar 12;245(1-2):65-75.
4 Functional assessment of human alcohol dehydrogenase family in ethanol metabolism: significance of first-pass metabolism. Alcohol Clin Exp Res. 2006 Jul;30(7):1132-42.
5 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
6 CYP2E1 and clinical features in alcoholics. Neuropsychobiology. 2003;47(2):86-9.
7 Identification and preliminary characterization of UDP-glucuronosyltransferases catalyzing formation of ethyl glucuronide. Anal Bioanal Chem. 2014 Apr;406(9-10):2325-32.

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