Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0023)
DME Name Cytochrome P450 1B1 (CYP1B1), Homo sapiens DME Info
UniProt ID
CP1B1_HUMAN
EC Number    EC: 1.14.14.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Streptomyces avermitilis (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Testosterone cypionate Click to Show/Hide the Detail
                                 Drug ID DR1564   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1B1 (CYP1B1) and Streptomyces avermitilis co-metabolize the drug Testosterone cypionate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2], [3]
      Bacteria: Bacteroidetes
                  Bacteroides coprophilus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1B1 (CYP1B1) and Bacteroides coprophilus co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [5]
                  Bacteroides dorei (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1B1 (CYP1B1) and Bacteroides dorei co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [5]
                  Bacteroides fragilis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1B1 (CYP1B1) and Bacteroides fragilis co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [5]
                              Rosuvastatin Click to Show/Hide the Detail
                                 Drug ID DR1445   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1B1 (CYP1B1) and Bacteroides fragilis co-metabolize the drug Rosuvastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [5]
                  Bacteroides ovatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1B1 (CYP1B1) and Bacteroides ovatus co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [5]
                  Bacteroides sartorii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1B1 (CYP1B1) and Bacteroides sartorii co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [5]
                  Bacteroides stercoris (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1B1 (CYP1B1) and Bacteroides stercoris co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [5]
                  Bacteroides thetaiotaomicron (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1B1 (CYP1B1) and Bacteroides thetaiotaomicron co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [5]
                  Bacteroides vulgatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1B1 (CYP1B1) and Bacteroides vulgatus co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [5]
                  Bacteroides xylanisolvens (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1B1 (CYP1B1) and Bacteroides xylanisolvens co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [5]
                  Odoribacter splanchnicus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1B1 (CYP1B1) and Odoribacter splanchnicus co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [5]
      Bacteria: Firmicutes
                  Bacillus megaterium (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Amodiaquine Click to Show/Hide the Detail
                                 Drug ID DR0102   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1B1 (CYP1B1) and Bacillus megaterium co-metabolize the drug Amodiaquine, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [8]
                              Progesterone Click to Show/Hide the Detail
                                 Drug ID DR1346   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1B1 (CYP1B1) and Bacillus megaterium co-metabolize the drug Progesterone, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [9]
                              Testosterone cypionate Click to Show/Hide the Detail
                                 Drug ID DR1564   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1B1 (CYP1B1) and Bacillus megaterium co-metabolize the drug Testosterone cypionate, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [9], [10]
                  Blautia hansenii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Rosuvastatin Click to Show/Hide the Detail
                                 Drug ID DR1445   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1B1 (CYP1B1) and Blautia hansenii co-metabolize the drug Rosuvastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [5]
                  Clostridium botulinum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1B1 (CYP1B1) and Clostridium botulinum co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [5]
                  Lactobacillus sakei (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Erythromycin stearate Click to Show/Hide the Detail
                                 Drug ID DR0614   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1B1 (CYP1B1) and Lactobacillus sakei co-metabolize the drug Erythromycin stearate, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [12], [13]
References
1 Catalytic properties of polymorphic human cytochrome P450 1B1 variants. Carcinogenesis. 1999 Aug;20(8):1607-13.
2 Regio- and stereoselective hydroxylation of testosterone by a novel cytochrome P450 154C2 from Streptomyces avermitilis. Biochem Biophys Res Commun. 2020 Feb 5;522(2):355-361.
3 The metagenome of Caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing. Data Brief. 2017 Nov 22;16:501-505.
4 Tumour cytochrome P450 and drug activation. Curr Pharm Des. 2002;8(15):1335-47.
5 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
6 Pharmacokinetics of rosuvastatin when coadministered with rifampicin in healthy males: a randomized, single-blind, placebo-controlled, crossover study. Clin Ther. 2008 Jul;30(7):1283-9.
7 Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate. J Pharmacol Exp Ther. 2002 Feb;300(2):399-407.
8 The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities. Trends Biotechnol. 2007 Jul;25(7):289-98.
9 acillus megaterium SF185 spores exert protective effects against oxidative stress in vivo and in vitro. Sci Rep. 2019 Aug 19;9(1):12082.
10 A Novel NADPH-dependent flavoprotein reductase from Bacillus megaterium acts as an efficient cytochrome P450 reductase. J Biotechnol. 2016 Aug 10;231:83-94.
11 Cytochromes P450 in crustacea. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1998 Nov;121(1-3):157-72.
12 Identification of Lactobacillus sakei genes induced during meat fermentation and their role in survival and growth. Appl Environ Microbiol. 2007 Apr;73(8):2522-31.
13 Degradation of various insecticides in cooked eggs during in vitro human digestion. Environ Pollut. 2018 Dec;243(Pt A):437-443.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.