Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0041)
DME Name UDP-glucuronosyltransferase 1A3 (UGT1A3), Homo sapiens DME Info
UniProt ID
UD13_HUMAN
EC Number    EC: 2.4.1.17     (Click to Show/Hide the Complete EC Tree)
Transferase
Glycosyltransferases
Hexosyltransferase
EC: 2.4.1.17
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Bifidobacterium adolescentis (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bifidobacterium adolescentis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bifidobacterium breve (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bifidobacterium breve co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bifidobacterium longum (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bifidobacterium longum co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
                  Bifidobacterium ruminatum (actinobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bifidobacterium ruminatum co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bifidobacterium ruminatum co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Collinsella aerofaciens (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Pitavastatin calcium Click to Show/Hide the Detail
                                 Drug ID DR1306   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Collinsella aerofaciens co-metabolize the drug Pitavastatin calcium, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Eggerthella lenta (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Eggerthella lenta co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Streptomyces avermitilis (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Streptomyces avermitilis co-metabolize the drug Diclofenac sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [7], [8]
      Bacteria: Bacteroidetes
                  Bacteroides cellulosilyticus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides cellulosilyticus co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Telmisartan Click to Show/Hide the Detail
                                 Drug ID DR1545   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides cellulosilyticus co-metabolize the drug Telmisartan, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                  Bacteroides dorei (CFB bacteria) Click to Show/Hide the Full List of Drugs:        5 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) metabolizes the drug Diclofenac sodium, and Bacteroides dorei further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [6], [10]
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides dorei co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides dorei co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides dorei co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Telmisartan Click to Show/Hide the Detail
                                 Drug ID DR1545   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides dorei co-metabolize the drug Telmisartan, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                  Bacteroides fragilis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        7 Drugs Metabolized
                              Etodolac Click to Show/Hide the Detail
                                 Drug ID DR0666   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides fragilis co-metabolize the drug Etodolac, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Ezetimibe Click to Show/Hide the Detail
                                 Drug ID DR0677   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides fragilis co-metabolize the drug Ezetimibe, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [2]
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides fragilis co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides fragilis co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides fragilis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides fragilis co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [12], [2]
                              Telmisartan Click to Show/Hide the Detail
                                 Drug ID DR1545   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides fragilis co-metabolize the drug Telmisartan, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                  Bacteroides intestinalis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides intestinalis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides ovatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Telmisartan Click to Show/Hide the Detail
                                 Drug ID DR1545   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides ovatus co-metabolize the drug Telmisartan, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                  Bacteroides sartorii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        7 Drugs Metabolized
                              Etodolac Click to Show/Hide the Detail
                                 Drug ID DR0666   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides sartorii co-metabolize the drug Etodolac, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Ezetimibe Click to Show/Hide the Detail
                                 Drug ID DR0677   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides sartorii co-metabolize the drug Ezetimibe, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [2]
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides sartorii co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides sartorii co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides sartorii co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides sartorii co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [12], [2]
                              Telmisartan Click to Show/Hide the Detail
                                 Drug ID DR1545   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides sartorii co-metabolize the drug Telmisartan, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                  Bacteroides stercoris (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Ezetimibe Click to Show/Hide the Detail
                                 Drug ID DR0677   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides stercoris co-metabolize the drug Ezetimibe, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [2]
                              Telmisartan Click to Show/Hide the Detail
                                 Drug ID DR1545   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides stercoris co-metabolize the drug Telmisartan, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                  Bacteroides thetaiotaomicron (CFB bacteria) Click to Show/Hide the Full List of Drugs:        6 Drugs Metabolized
                              Etodolac Click to Show/Hide the Detail
                                 Drug ID DR0666   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides thetaiotaomicron co-metabolize the drug Etodolac, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Ezetimibe Click to Show/Hide the Detail
                                 Drug ID DR0677   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides thetaiotaomicron co-metabolize the drug Ezetimibe, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [2]
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides thetaiotaomicron co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides thetaiotaomicron co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides thetaiotaomicron co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [12], [2]
                              Telmisartan Click to Show/Hide the Detail
                                 Drug ID DR1545   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides thetaiotaomicron co-metabolize the drug Telmisartan, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                  Bacteroides uniformis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides uniformis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides vulgatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        5 Drugs Metabolized
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides vulgatus co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides vulgatus co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides vulgatus co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides vulgatus co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [12], [2]
                              Telmisartan Click to Show/Hide the Detail
                                 Drug ID DR1545   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides vulgatus co-metabolize the drug Telmisartan, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                  Bacteroides xylanisolvens (CFB bacteria) Click to Show/Hide the Full List of Drugs:        7 Drugs Metabolized
                              Etodolac Click to Show/Hide the Detail
                                 Drug ID DR0666   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides xylanisolvens co-metabolize the drug Etodolac, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Ezetimibe Click to Show/Hide the Detail
                                 Drug ID DR0677   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides xylanisolvens co-metabolize the drug Ezetimibe, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [2]
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides xylanisolvens co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides xylanisolvens co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides xylanisolvens co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides xylanisolvens co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [12], [2]
                              Telmisartan Click to Show/Hide the Detail
                                 Drug ID DR1545   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacteroides xylanisolvens co-metabolize the drug Telmisartan, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                  Odoribacter splanchnicus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        7 Drugs Metabolized
                              Etodolac Click to Show/Hide the Detail
                                 Drug ID DR0666   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Odoribacter splanchnicus co-metabolize the drug Etodolac, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Ezetimibe Click to Show/Hide the Detail
                                 Drug ID DR0677   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Odoribacter splanchnicus co-metabolize the drug Ezetimibe, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [2]
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Odoribacter splanchnicus co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Odoribacter splanchnicus co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Odoribacter splanchnicus co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Odoribacter splanchnicus co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [12], [2]
                              Telmisartan Click to Show/Hide the Detail
                                 Drug ID DR1545   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Odoribacter splanchnicus co-metabolize the drug Telmisartan, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                  Parabacteroides distasonis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Parabacteroides distasonis co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Parabacteroides distasonis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Parabacteroides distasonis co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [12], [2]
                              Telmisartan Click to Show/Hide the Detail
                                 Drug ID DR1545   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Parabacteroides distasonis co-metabolize the drug Telmisartan, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                  Parabacteroides johnsonii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Parabacteroides johnsonii co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Parabacteroides johnsonii co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Parabacteroides johnsonii co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Parabacteroides merdae (CFB bacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Parabacteroides merdae co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Parabacteroides merdae co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Parabacteroides merdae co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Prevotella copri (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Prevotella copri co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Firmicutes
                  Bacillus megaterium (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacillus megaterium co-metabolize the drug Diclofenac sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [13]
                  Bacillus pumilus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Gemfibrozil Click to Show/Hide the Detail
                                 Drug ID DR0766   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Bacillus pumilus co-metabolize the drug Gemfibrozil, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [15]
                  Blautia hansenii (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Anastrozole Click to Show/Hide the Detail
                                 Drug ID DR0113   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Blautia hansenii co-metabolize the drug Anastrozole, which can collectively affect efficacy, safety or bioavailability of this drug. [16], [2]
                              Etodolac Click to Show/Hide the Detail
                                 Drug ID DR0666   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Blautia hansenii co-metabolize the drug Etodolac, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                              Irbesartan Click to Show/Hide the Detail
                                 Drug ID DR0879   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Blautia hansenii co-metabolize the drug Irbesartan, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [2]
                  Clostridium botulinum (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Anastrozole Click to Show/Hide the Detail
                                 Drug ID DR0113   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Clostridium botulinum co-metabolize the drug Anastrozole, which can collectively affect efficacy, safety or bioavailability of this drug. [16], [2]
                              Ezetimibe Click to Show/Hide the Detail
                                 Drug ID DR0677   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Clostridium botulinum co-metabolize the drug Ezetimibe, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Clostridium botulinum co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Clostridium perfringens (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Clostridium perfringens co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
                  Clostridium sporogenes (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Ezetimibe Click to Show/Hide the Detail
                                 Drug ID DR0677   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Clostridium sporogenes co-metabolize the drug Ezetimibe, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [2]
                  Enterocloster asparagiformis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Enterocloster asparagiformis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Eubacterium limosum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Eubacterium limosum co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
                  Faecalibacterium prausnitzii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) metabolizes the drug Diclofenac sodium, and Faecalibacterium prausnitzii further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [6], [10]
                  Holdemanella biformis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Holdemanella biformis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Lactobacillus rhamnosus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) metabolizes the drug Diclofenac sodium, and Lactobacillus rhamnosus further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [6], [10]
                  Ruminococcus gnavus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) metabolizes the drug Diclofenac sodium, and Ruminococcus gnavus further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [6], [10]
      Bacteria: Fusobacteria
                  Fusobacterium varium (fusobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Fusobacterium varium co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
      Bacteria: Lentisphaerae
                  Victivallis vadensis (PVC bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Victivallis vadensis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Proteobacteria
                  Sphingomonas colocasiae (alpha-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Ibuprofen Click to Show/Hide the Detail
                                 Drug ID DR0844   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 1A3 (UGT1A3) and Sphingomonas colocasiae co-metabolize the drug Ibuprofen, which can collectively affect efficacy, safety or bioavailability of this drug. [4], [17]
References
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2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
3 In vitro susceptibility of cultured human methanogens to lovastatin. Int J Antimicrob Agents. 2017 Feb;49(2):176-182.
4 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
5 Pitavastatin: a review in hypercholesterolemia. Am J Cardiovasc Drugs. 2017 Apr;17(2):157-168.
6 Glucuronidation of nonsteroidal anti-inflammatory drugs: identifying the enzymes responsible in human liver microsomes. Drug Metab Dispos. 2005 Jul;33(7):1027-35.
7 The metagenome of Caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing. Data Brief. 2017 Nov 22;16:501-505.
8 Hydroxylation of Compactin (ML-236B) by CYP105D7 (SAV_7469) from Streptomyces avermitilis. J Microbiol Biotechnol. 2017 May 28;27(5):956-964.
9 Characterization of in vitro glucuronidation clearance of a range of drugs in human kidney microsomes: comparison with liver and intestinal glucuronidation and impact of albumin. Drug Metab Dispos. 2012 Apr;40(4):825-35.
10 tructure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases. Sci Rep. 2019 Jan 29;9(1):825.
11 Drug interactions between the immunosuppressant tacrolimus and the cholesterol absorption inhibitor ezetimibe in healthy volunteers. Clin Pharmacol Ther. 2011 Apr;89(4):524-8.
12 S-Naproxen and desmethylnaproxen glucuronidation by human liver microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT2B7 in the elimination of naproxen. Br J Clin Pharmacol. 2005 Oct;60(4):423-33.
13 Both reactivity and accessibility are important in cytochrome P450 metabolism: a combined DFT and MD study of fenamic acids in BM3 mutants. J Chem Inf Model. 2019 Feb 25;59(2):743-753.
14 Comprehensive pharmacogenomic study reveals an important role of UGT1A3 in montelukast pharmacokinetics. Clin Pharmacol Ther. 2018 Jul;104(1):158-168.
15 Genomic, proteomic, and metabolite characterization of gemfibrozil-degrading organism Bacillus sp. GeD10. Environ Sci Technol. 2016 Jan 19;50(2):744-55.
16 In vitro and in vivo oxidative metabolism and glucuronidation of anastrozole. Br J Clin Pharmacol. 2010 Dec;70(6):854-69.
17 Genetic and chemical characterization of ibuprofen degradation by Sphingomonas Ibu-2. Microbiology. 2013 Mar;159(Pt 3):621-632.

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