Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0042)
DME Name	UDP-glucuronosyltransferase 1A9 (UGT1A9), Homo sapiens	DME Info
UniProt ID	UD19_HUMAN
EC Number	EC: 2.4.1.17 (Click to Show/Hide the Complete EC Tree) Transferase Glycosyltransferases Hexosyltransferase EC: 2.4.1.17
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Interactions between Microbiome and DME (MICBIO)
Bacteria: Actinobacteria
Bifidobacterium adolescentis (actinobacteria)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bifidobacterium adolescentis co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bifidobacterium adolescentis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Bifidobacterium breve (actinobacteria)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bifidobacterium breve co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bifidobacterium breve co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Bifidobacterium longum (actinobacteria)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bifidobacterium longum co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bifidobacterium longum co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Bifidobacterium ruminatum (actinobacteria)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bifidobacterium ruminatum co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bifidobacterium ruminatum co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Collinsella aerofaciens (actinobacteria)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
Fenofibrate		Click to Show/Hide the Detail
Drug ID	DR0688 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Collinsella aerofaciens co-metabolize the drug Fenofibrate, which can collectively affect efficacy, safety or bioavailability of this drug.		[4], [2]
Collinsella intestinalis (actinobacteria)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Collinsella intestinalis co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Collinsella intestinalis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Eggerthella lenta (actinobacteria)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Eggerthella lenta co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Eggerthella lenta co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Streptomyces avermitilis (actinobacteria)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
Diclofenac sodium		Click to Show/Hide the Detail
Drug ID	DR0488 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Streptomyces avermitilis co-metabolize the drug Diclofenac sodium, which can collectively affect efficacy, safety or bioavailability of this drug.		[5], [6], [7]
Bacteria: Bacteroidetes
Alistipes indistinctus (CFB bacteria)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Alistipes indistinctus co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Alistipes indistinctus co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Bacteroides cellulosilyticus (CFB bacteria)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides cellulosilyticus co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Bacteroides coprophilus (CFB bacteria)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides coprophilus co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Bacteroides dorei (CFB bacteria)		Click to Show/Hide the Full List of Drugs: 3 Drugs Metabolized
Diclofenac sodium		Click to Show/Hide the Detail
Drug ID	DR0488 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) metabolizes the drug Diclofenac sodium, and Bacteroides dorei further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug.		[5], [8]
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides dorei co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides dorei co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Bacteroides eggerthii (CFB bacteria)		Click to Show/Hide the Full List of Drugs: 4 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides eggerthii co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Fenofibrate		Click to Show/Hide the Detail
Drug ID	DR0688 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides eggerthii co-metabolize the drug Fenofibrate, which can collectively affect efficacy, safety or bioavailability of this drug.		[4], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides eggerthii co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Nateglinide		Click to Show/Hide the Detail
Drug ID	DR1132 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides eggerthii co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug.		[9], [2]
Bacteroides finegoldii (CFB bacteria)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides finegoldii co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Bacteroides fragilis (CFB bacteria)		Click to Show/Hide the Full List of Drugs: 7 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides fragilis co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Etodolac		Click to Show/Hide the Detail
Drug ID	DR0666 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides fragilis co-metabolize the drug Etodolac, which can collectively affect efficacy, safety or bioavailability of this drug.		[9], [2]
Fenofibrate		Click to Show/Hide the Detail
Drug ID	DR0688 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides fragilis co-metabolize the drug Fenofibrate, which can collectively affect efficacy, safety or bioavailability of this drug.		[4], [2]
Indomethacin		Click to Show/Hide the Detail
Drug ID	DR0875 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides fragilis co-metabolize the drug Indomethacin, which can collectively affect efficacy, safety or bioavailability of this drug.		[10], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides fragilis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Naproxen		Click to Show/Hide the Detail
Drug ID	DR1130 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides fragilis co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug.		[11], [2]
Nateglinide		Click to Show/Hide the Detail
Drug ID	DR1132 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides fragilis co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug.		[9], [2]
Bacteroides intestinalis (CFB bacteria)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides intestinalis co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides intestinalis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Bacteroides ovatus (CFB bacteria)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides ovatus co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides ovatus co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Bacteroides sartorii (CFB bacteria)		Click to Show/Hide the Full List of Drugs: 6 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides sartorii co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Etodolac		Click to Show/Hide the Detail
Drug ID	DR0666 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides sartorii co-metabolize the drug Etodolac, which can collectively affect efficacy, safety or bioavailability of this drug.		[9], [2]
Indomethacin		Click to Show/Hide the Detail
Drug ID	DR0875 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides sartorii co-metabolize the drug Indomethacin, which can collectively affect efficacy, safety or bioavailability of this drug.		[10], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides sartorii co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Naproxen		Click to Show/Hide the Detail
Drug ID	DR1130 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides sartorii co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug.		[11], [2]
Nateglinide		Click to Show/Hide the Detail
Drug ID	DR1132 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides sartorii co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug.		[9], [2]
Bacteroides stercoris (CFB bacteria)		Click to Show/Hide the Full List of Drugs: 3 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides stercoris co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Indomethacin		Click to Show/Hide the Detail
Drug ID	DR0875 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides stercoris co-metabolize the drug Indomethacin, which can collectively affect efficacy, safety or bioavailability of this drug.		[10], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides stercoris co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Bacteroides thetaiotaomicron (CFB bacteria)		Click to Show/Hide the Full List of Drugs: 7 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides thetaiotaomicron co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Etodolac		Click to Show/Hide the Detail
Drug ID	DR0666 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides thetaiotaomicron co-metabolize the drug Etodolac, which can collectively affect efficacy, safety or bioavailability of this drug.		[9], [2]
Indomethacin		Click to Show/Hide the Detail
Drug ID	DR0875 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides thetaiotaomicron co-metabolize the drug Indomethacin, which can collectively affect efficacy, safety or bioavailability of this drug.		[10], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides thetaiotaomicron co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Naproxen		Click to Show/Hide the Detail
Drug ID	DR1130 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides thetaiotaomicron co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug.		[11], [2]
Nateglinide		Click to Show/Hide the Detail
Drug ID	DR1132 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides thetaiotaomicron co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug.		[9], [2]
SN-38		Click to Show/Hide the Detail
Drug ID	DR0024 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) metabolizes the drug SN-38, while Bacteroides thetaiotaomicron further converts its metabolite SN-38G back to SN-38, which leads to delayed-onset, severe diarrhea and limits the effective dose administered.		[12], [13]
Bacteroides uniformis (CFB bacteria)		Click to Show/Hide the Full List of Drugs: 3 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides uniformis co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides uniformis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
SN-38		Click to Show/Hide the Detail
Drug ID	DR0024 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) metabolizes the drug SN-38, while Bacteroides uniformis further converts its metabolite SN-38G back to SN-38, which leads to delayed-onset, severe diarrhea and limits the effective dose administered.		[12], [13]
Bacteroides vulgatus (CFB bacteria)		Click to Show/Hide the Full List of Drugs: 5 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides vulgatus co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Indomethacin		Click to Show/Hide the Detail
Drug ID	DR0875 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) metabolizes the drug Indomethacin, and Bacteroides vulgatus further metabolizes its metabolite (Indomethacin glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug.		[10], [14]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides vulgatus co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Naproxen		Click to Show/Hide the Detail
Drug ID	DR1130 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides vulgatus co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug.		[11], [2]
Nateglinide		Click to Show/Hide the Detail
Drug ID	DR1132 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides vulgatus co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug.		[9], [2]
Bacteroides xylanisolvens (CFB bacteria)		Click to Show/Hide the Full List of Drugs: 6 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides xylanisolvens co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Etodolac		Click to Show/Hide the Detail
Drug ID	DR0666 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides xylanisolvens co-metabolize the drug Etodolac, which can collectively affect efficacy, safety or bioavailability of this drug.		[9], [2]
Indomethacin		Click to Show/Hide the Detail
Drug ID	DR0875 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides xylanisolvens co-metabolize the drug Indomethacin, which can collectively affect efficacy, safety or bioavailability of this drug.		[10], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides xylanisolvens co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Naproxen		Click to Show/Hide the Detail
Drug ID	DR1130 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides xylanisolvens co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug.		[11], [2]
Nateglinide		Click to Show/Hide the Detail
Drug ID	DR1132 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides xylanisolvens co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug.		[9], [2]
Odoribacter splanchnicus (CFB bacteria)		Click to Show/Hide the Full List of Drugs: 6 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Odoribacter splanchnicus co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Etodolac		Click to Show/Hide the Detail
Drug ID	DR0666 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Odoribacter splanchnicus co-metabolize the drug Etodolac, which can collectively affect efficacy, safety or bioavailability of this drug.		[9], [2]
Indomethacin		Click to Show/Hide the Detail
Drug ID	DR0875 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Odoribacter splanchnicus co-metabolize the drug Indomethacin, which can collectively affect efficacy, safety or bioavailability of this drug.		[10], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Odoribacter splanchnicus co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Naproxen		Click to Show/Hide the Detail
Drug ID	DR1130 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Odoribacter splanchnicus co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug.		[11], [2]
Nateglinide		Click to Show/Hide the Detail
Drug ID	DR1132 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Odoribacter splanchnicus co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug.		[9], [2]
Parabacteroides distasonis (CFB bacteria)		Click to Show/Hide the Full List of Drugs: 4 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Parabacteroides distasonis co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Parabacteroides distasonis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Naproxen		Click to Show/Hide the Detail
Drug ID	DR1130 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Parabacteroides distasonis co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug.		[11], [2]
Nateglinide		Click to Show/Hide the Detail
Drug ID	DR1132 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Parabacteroides distasonis co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug.		[9], [2]
Parabacteroides johnsonii (CFB bacteria)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Parabacteroides johnsonii co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Parabacteroides johnsonii co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Parabacteroides merdae (CFB bacteria)		Click to Show/Hide the Full List of Drugs: 4 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Parabacteroides merdae co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Indomethacin		Click to Show/Hide the Detail
Drug ID	DR0875 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Parabacteroides merdae co-metabolize the drug Indomethacin, which can collectively affect efficacy, safety or bioavailability of this drug.		[10], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Parabacteroides merdae co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Nateglinide		Click to Show/Hide the Detail
Drug ID	DR1132 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Parabacteroides merdae co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug.		[9], [2]
Prevotella copri (CFB bacteria)		Click to Show/Hide the Full List of Drugs: 3 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Prevotella copri co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Fenofibrate		Click to Show/Hide the Detail
Drug ID	DR0688 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Prevotella copri co-metabolize the drug Fenofibrate, which can collectively affect efficacy, safety or bioavailability of this drug.		[4], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Prevotella copri co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Bacteria: Firmicutes
Anaerobutyricum hallii (firmicutes)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Anaerobutyricum hallii co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Anaerobutyricum hallii co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Anaerococcus hydrogenalis (firmicutes)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Anaerococcus hydrogenalis co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Anaerococcus hydrogenalis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Anaerostipes hadrus (firmicutes)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Anaerostipes hadrus co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Anaerostipes hadrus co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Anaerotruncus colihominis (firmicutes)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Anaerotruncus colihominis co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Bacillus megaterium (firmicutes)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Acetaminophen		Click to Show/Hide the Detail
Drug ID	DR0037 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacillus megaterium co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug.		[15], [16]
Diclofenac sodium		Click to Show/Hide the Detail
Drug ID	DR0488 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacillus megaterium co-metabolize the drug Diclofenac sodium, which can collectively affect efficacy, safety or bioavailability of this drug.		[5], [17]
Bacillus pumilus (firmicutes)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
Gemfibrozil		Click to Show/Hide the Detail
Drug ID	DR0766 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacillus pumilus co-metabolize the drug Gemfibrozil, which can collectively affect efficacy, safety or bioavailability of this drug.		[18], [19]
Bacteroides pectinophilus (firmicutes)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides pectinophilus co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Bacteroides pectinophilus co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Blautia hansenii (firmicutes)		Click to Show/Hide the Full List of Drugs: 4 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Blautia hansenii co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Etodolac		Click to Show/Hide the Detail
Drug ID	DR0666 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Blautia hansenii co-metabolize the drug Etodolac, which can collectively affect efficacy, safety or bioavailability of this drug.		[9], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Blautia hansenii co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Nateglinide		Click to Show/Hide the Detail
Drug ID	DR1132 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Blautia hansenii co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug.		[9], [2]
Blautia luti (firmicutes)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Blautia luti co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Blautia luti co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Clostridioides difficile (firmicutes)		Click to Show/Hide the Full List of Drugs: 4 Drugs Metabolized
Acetaminophen		Click to Show/Hide the Detail
Drug ID	DR0037 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Clostridioides difficile co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug.		[15], [20]
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Clostridioides difficile co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Fenofibrate		Click to Show/Hide the Detail
Drug ID	DR0688 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Clostridioides difficile co-metabolize the drug Fenofibrate, which can collectively affect efficacy, safety or bioavailability of this drug.		[4], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Clostridioides difficile co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Clostridium botulinum (firmicutes)		Click to Show/Hide the Full List of Drugs: 3 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Clostridium botulinum co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Clostridium botulinum co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Nateglinide		Click to Show/Hide the Detail
Drug ID	DR1132 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Clostridium botulinum co-metabolize the drug Nateglinide, which can collectively affect efficacy, safety or bioavailability of this drug.		[9], [2]
Clostridium perfringens (firmicutes)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
SN-38		Click to Show/Hide the Detail
Drug ID	DR0024 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) metabolizes the drug SN-38, while Clostridium perfringens further converts its metabolite SN-38G back to SN-38, which leads to delayed-onset, severe diarrhea and limits the effective dose administered.		[12], [21]
Clostridium scindens (firmicutes)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Clostridium scindens co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Clostridium scindens co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Clostridium spiroforme (firmicutes)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Clostridium spiroforme co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Clostridium spiroforme co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Clostridium sporogenes (firmicutes)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Clostridium sporogenes co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Clostridium symbiosum (firmicutes)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Clostridium symbiosum co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Coprococcus comes (firmicutes)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Coprococcus comes co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Coprococcus comes co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Dorea formicigenerans (firmicutes)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Dorea formicigenerans co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Dorea formicigenerans co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Enterocloster asparagiformis (firmicutes)		Click to Show/Hide the Full List of Drugs: 3 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Enterocloster asparagiformis co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Fenofibrate		Click to Show/Hide the Detail
Drug ID	DR0688 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Enterocloster asparagiformis co-metabolize the drug Fenofibrate, which can collectively affect efficacy, safety or bioavailability of this drug.		[4], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Enterocloster asparagiformis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Enterocloster bolteae (firmicutes)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Enterocloster bolteae co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Enterocloster bolteae co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Enterococcus faecalis (firmicutes)		Click to Show/Hide the Full List of Drugs: 3 Drugs Metabolized
Acetaminophen		Click to Show/Hide the Detail
Drug ID	DR0037 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Enterococcus faecalis co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug.		[15], [20]
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Enterococcus faecalis co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Enterococcus faecalis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Erysipelatoclostridium ramosum (firmicutes)		Click to Show/Hide the Full List of Drugs: 3 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Erysipelatoclostridium ramosum co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Indomethacin		Click to Show/Hide the Detail
Drug ID	DR0875 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) metabolizes the drug Indomethacin, and Erysipelatoclostridium ramosum further metabolizes its metabolite (Indomethacin glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug.		[10], [14]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Erysipelatoclostridium ramosum co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Eubacterium rectale (firmicutes)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Eubacterium rectale co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Eubacterium rectale co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Eubacterium ventriosum (firmicutes)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Eubacterium ventriosum co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Faecalibacterium prausnitzii (firmicutes)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
Diclofenac sodium		Click to Show/Hide the Detail
Drug ID	DR0488 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) metabolizes the drug Diclofenac sodium, and Faecalibacterium prausnitzii further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug.		[5], [8]
Holdemanella biformis (firmicutes)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Holdemanella biformis co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Holdemanella biformis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Hungatella hathewayi (firmicutes)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Hungatella hathewayi co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Hungatella hathewayi co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Lactobacillus reuteri (firmicutes)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Lactobacillus reuteri co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Lactobacillus rhamnosus (firmicutes)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
Diclofenac sodium		Click to Show/Hide the Detail
Drug ID	DR0488 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) metabolizes the drug Diclofenac sodium, and Lactobacillus rhamnosus further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug.		[5], [8]
Marvinbryantia formatexigens (firmicutes)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Marvinbryantia formatexigens co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Marvinbryantia formatexigens co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Roseburia hominis (firmicutes)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
Indomethacin		Click to Show/Hide the Detail
Drug ID	DR0875 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) metabolizes the drug Indomethacin, and Roseburia hominis further metabolizes its metabolite (Indomethacin glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug.		[10], [14]
Roseburia intestinalis (firmicutes)		Click to Show/Hide the Full List of Drugs: 3 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Roseburia intestinalis co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Indomethacin		Click to Show/Hide the Detail
Drug ID	DR0875 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) metabolizes the drug Indomethacin, and Roseburia intestinalis further metabolizes its metabolite (Indomethacin glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug.		[10], [14]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Roseburia intestinalis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Ruminococcus gnavus (firmicutes)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Diclofenac sodium		Click to Show/Hide the Detail
Drug ID	DR0488 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) metabolizes the drug Diclofenac sodium, and Ruminococcus gnavus further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug.		[5], [8]
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Ruminococcus gnavus co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Ruminococcus lactaris (firmicutes)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Ruminococcus lactaris co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Ruminococcus torques (firmicutes)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Ruminococcus torques co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Ruminococcus torques co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Streptococcus agalactiae (firmicutes)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
SN-38		Click to Show/Hide the Detail
Drug ID	DR0024 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) metabolizes the drug SN-38, while Streptococcus agalactiae further converts its metabolite SN-38G back to SN-38, which leads to delayed-onset, severe diarrhea and limits the effective dose administered.		[12], [21]
Subdoligranulum variabile (firmicutes)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Subdoligranulum variabile co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Subdoligranulum variabile co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Bacteria: Lentisphaerae
Victivallis vadensis (PVC bacteria)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Victivallis vadensis co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Victivallis vadensis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Bacteria: Proteobacteria
Citrobacter freundii (enterobacteria)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
Acetaminophen		Click to Show/Hide the Detail
Drug ID	DR0037 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Citrobacter freundii co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug.		[15], [20]
Edwardsiella tarda (enterobacteria)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Edwardsiella tarda co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Edwardsiella tarda co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Enterobacter cancerogenus (enterobacteria)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Enterobacter cancerogenus co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Escherichia coli (enterobacteria)		Click to Show/Hide the Full List of Drugs: 6 Drugs Metabolized
Acetaminophen		Click to Show/Hide the Detail
Drug ID	DR0037 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Escherichia coli co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug.		[15], [20]
Curcumin		Click to Show/Hide the Detail
Drug ID	DR1941 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Escherichia coli co-metabolize the drug Curcumin, which can collectively affect efficacy, safety or bioavailability of this drug.		[22], [23]
Indomethacin		Click to Show/Hide the Detail
Drug ID	DR0875 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) metabolizes the drug Indomethacin, and Escherichia coli further metabolizes its metabolite (Indomethacin glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug.		[10], [24]
Irinotecan hydrochloride		Click to Show/Hide the Detail
Drug ID	DR0881 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Escherichia coli co-metabolize the drug Irinotecan hydrochloride, which can collectively affect efficacy, safety or bioavailability of this drug.		[12], [25]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Escherichia coli co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
SN-38		Click to Show/Hide the Detail
Drug ID	DR0024 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) metabolizes the drug SN-38, while Escherichia coli further converts its metabolite SN-38G back to SN-38, which leads to delayed-onset, severe diarrhea and limits the effective dose administered.		[12], [25]
Proteus penneri (enterobacteria)		Click to Show/Hide the Full List of Drugs: 3 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Proteus penneri co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Fenofibrate		Click to Show/Hide the Detail
Drug ID	DR0688 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Proteus penneri co-metabolize the drug Fenofibrate, which can collectively affect efficacy, safety or bioavailability of this drug.		[4], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Proteus penneri co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Providencia alcalifaciens (enterobacteria)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Providencia alcalifaciens co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Providencia rettgeri (enterobacteria)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Providencia rettgeri co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Providencia stuartii (enterobacteria)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Providencia stuartii co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Salmonella enterica (enterobacteria)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Salmonella enterica co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Shewanella oneidensis (gamma-proteobacteria)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
Sulfamethoxazole		Click to Show/Hide the Detail
Drug ID	DR1511 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Shewanella oneidensis co-metabolize the drug Sulfamethoxazole, which can collectively affect efficacy, safety or bioavailability of this drug.		[9], [26], [27]
Sphingomonas colocasiae (alpha-proteobacteria)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
Ibuprofen		Click to Show/Hide the Detail
Drug ID	DR0844 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Sphingomonas colocasiae co-metabolize the drug Ibuprofen, which can collectively affect efficacy, safety or bioavailability of this drug.		[9], [28]
Bacteria: Synergistetes
Synergistetes bacterium (synergistetes)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
Sulfamethoxazole		Click to Show/Hide the Detail
Drug ID	DR1511 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Synergistetes bacterium co-metabolize the drug Sulfamethoxazole, which can collectively affect efficacy, safety or bioavailability of this drug.		[9], [29], [30]
Bacteria: Verrucomicrobia
Akkermansia muciniphila (verrucomicrobiae)		Click to Show/Hide the Full List of Drugs: 2 Drugs Metabolized
Entacapone		Click to Show/Hide the Detail
Drug ID	DR0581 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Akkermansia muciniphila co-metabolize the drug Entacapone, which can collectively affect efficacy, safety or bioavailability of this drug.		[1], [2]
Mycophenolate mofetil		Click to Show/Hide the Detail
Drug ID	DR1118 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) and Akkermansia muciniphila co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug.		[3], [2]
Fungi: Ascomycota
Saccharomyces cerevisiae (ascomycota)		Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
Acetaminophen		Click to Show/Hide the Detail
Drug ID	DR0037 Drug Info
Interaction Mechanism	Human UDP-glucuronosyltransferase 1A9 (UGT1A9) metabolizes the drug Acetaminophen, and Saccharomyces cerevisiae further metabolizes its metabolite (1-Phenyl-1,2-propanedione), which can indirectly affect efficacy, safety or bioavailability of this drug.		[15], [20]

References
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2	Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
3	The evolution of population pharmacokinetic models to describe the enterohepatic recycling of mycophenolic acid in solid organ transplantation and autoimmune disease. Clin Pharmacokinet. 2011 Jan;50(1):1-24.
4	Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos. 2004 Nov;32(11):1201-8.
5	Glucuronidation of nonsteroidal anti-inflammatory drugs: identifying the enzymes responsible in human liver microsomes. Drug Metab Dispos. 2005 Jul;33(7):1027-35.
6	The metagenome of Caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing. Data Brief. 2017 Nov 22;16:501-505.
7	Hydroxylation of Compactin (ML-236B) by CYP105D7 (SAV_7469) from Streptomyces avermitilis. J Microbiol Biotechnol. 2017 May 28;27(5):956-964.
8	tructure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases. Sci Rep. 2019 Jan 29;9(1):825.
9	Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
10	Contribution of UDP-glucuronosyltransferases 1A9 and 2B7 to the glucuronidation of indomethacin in the human liver. Eur J Clin Pharmacol. 2007 Mar;63(3):289-96.
11	S-Naproxen and desmethylnaproxen glucuronidation by human liver microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT2B7 in the elimination of naproxen. Br J Clin Pharmacol. 2005 Oct;60(4):423-33.
12	Clinical pharmacokinetics of irinotecan. Clin Pharmacokinet. 1997 Oct;33(4):245-59.
13	Three structurally and functionally distinct beta-glucuronidases from the human gut microbe Bacteroides uniformis. J Biol Chem. 2018 Nov 30;293(48):18559-18573.
14	Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31.
15	Polymorphic expression of UGT1A9 is associated with variable acetaminophen glucuronidation in neonates: a population pharmacokinetic and pharmacogenetic study. Clin Pharmacokinet. 2018 Oct;57(10):1325-1336.
16	The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities. Trends Biotechnol. 2007 Jul;25(7):289-98.
17	Both reactivity and accessibility are important in cytochrome P450 metabolism: a combined DFT and MD study of fenamic acids in BM3 mutants. J Chem Inf Model. 2019 Feb 25;59(2):743-753.
18	The UDP-glucuronosyltransferase 2B7 isozyme is responsible for gemfibrozil glucuronidation in the human liver. Drug Metab Dispos. 2007 Nov;35(11):2040-4.
19	Genomic, proteomic, and metabolite characterization of gemfibrozil-degrading organism Bacillus sp. GeD10. Environ Sci Technol. 2016 Jan 19;50(2):744-55.
20	Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice. J Hepatol. 2018 Jul;69(1):51-59.
21	Structure and inhibition of microbiome beta-glucuronidases essential to the alleviation of cancer drug toxicity. Chem Biol. 2015 Sep 17;22(9):1238-49.
22	Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem. 2004 Jan 9;279(2):1429-41.
23	Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism. Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6615-20.
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26	Biodegradation of sulfonamides by Shewanella oneidensis MR-1 and Shewanella sp. strain MR-4. Biodegradation. 2018 Apr;29(2):129-140.
27	The 285 kDa Bap/RTX hybrid cell surface protein (SO4317) of Shewanella oneidensis MR-1 is a key mediator of biofilm formation. Res Microbiol. 2010 Mar;161(2):144-52.
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30	Distributions of Synergistetes in clinically-healthy and diseased periodontal and peri-implant niches. Microb Pathog. 2016 May;94:90-103.

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