Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0097)
DME Name Quinone reductase 1 (NQO1), Homo sapiens DME Info
UniProt ID
NQO1_HUMAN
EC Number    EC: 1.6.5.2     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
NADH/NADPH oxidoreductase
Quinone acceptor oxidoreductase
EC: 1.6.5.2
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Bifidobacterium breve (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              CBL-954 Click to Show/Hide the Detail
                                 Drug ID DR1787   Drug Info
                                 Interaction Mechanism Human Quinone reductase 1 (NQO1) and Bifidobacterium breve co-metabolize the drug CBL-954, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Streptomyces griseus (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Doxorubicin Click to Show/Hide the Detail
                                 Drug ID DR0546   Drug Info
                                 Interaction Mechanism Human Quinone reductase 1 (NQO1) and Streptomyces griseus co-metabolize the drug Doxorubicin, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [4]
      Bacteria: Bacteroidetes
                  Prevotella copri (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Carboplatin Click to Show/Hide the Detail
                                 Drug ID DR0272   Drug Info
                                 Interaction Mechanism Human Quinone reductase 1 (NQO1) and Prevotella copri co-metabolize the drug Carboplatin, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [6]
      Bacteria: Firmicutes
                  Bacillus subtilis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              CBL-954 Click to Show/Hide the Detail
                                 Drug ID DR1787   Drug Info
                                 Interaction Mechanism Human Quinone reductase 1 (NQO1) and Bacillus subtilis co-metabolize the drug CBL-954, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [7]
                  Lactobacillus reuteri (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              CBL-954 Click to Show/Hide the Detail
                                 Drug ID DR1787   Drug Info
                                 Interaction Mechanism Human Quinone reductase 1 (NQO1) and Lactobacillus reuteri co-metabolize the drug CBL-954, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Lactococcus lactis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              CBL-954 Click to Show/Hide the Detail
                                 Drug ID DR1787   Drug Info
                                 Interaction Mechanism Human Quinone reductase 1 (NQO1) and Lactococcus lactis co-metabolize the drug CBL-954, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Proteobacteria
                  Escherichia coli (enterobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              CBL-954 Click to Show/Hide the Detail
                                 Drug ID DR1787   Drug Info
                                 Interaction Mechanism Human Quinone reductase 1 (NQO1) and Escherichia coli co-metabolize the drug CBL-954, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [8]
                              Doxorubicin Click to Show/Hide the Detail
                                 Drug ID DR0546   Drug Info
                                 Interaction Mechanism Human Quinone reductase 1 (NQO1) and Escherichia coli co-metabolize the drug Doxorubicin, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [9]
                  Klebsiella pneumoniae (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Doxorubicin Click to Show/Hide the Detail
                                 Drug ID DR0546   Drug Info
                                 Interaction Mechanism Human Quinone reductase 1 (NQO1) and Klebsiella pneumoniae co-metabolize the drug Doxorubicin, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [9]
                  Raoultella planticola (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Doxorubicin Click to Show/Hide the Detail
                                 Drug ID DR0546   Drug Info
                                 Interaction Mechanism Human Quinone reductase 1 (NQO1) and Raoultella planticola co-metabolize the drug Doxorubicin, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [9]
References
1 Gene Therapy of the Central Nervous System. Charter 22 - Prodrug-Activation Gene Therapy. 2006, Pages 291-301
2 Activation of multiple chemotherapeutic prodrugs by the natural enzymolome of tumour-localised probiotic bacteria. J Control Release. 2016 Jan 28;222:9-17.
3 Differential ability of cytostatics from anthraquinone group to generate free radicals in three enzymatic systems: NADH dehydrogenase, NADPH cytochrome P450 reductase, and xanthine oxidase. Oncol Res. 2003;13(5):245-52.
4 Bacterial inactivation of the anticancer drug doxorubicin. Chem Biol. 2012 Oct 26;19(10):1255-64.
5 PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150642262)
6 revotella copri is associated with carboplatin-induced gut toxicity. Cell Death Dis. 2019 Sep 26;10(10):714.
7 Bacillus amyloliquefaciens orthologue of Bacillus subtilis ywrO encodes a nitroreductase enzyme which activates the prodrug CB 1954. Microbiology. 2002 Jan;148(Pt 1):297-306.
8 Conversion of NfsB, a minor Escherichia coli nitroreductase, to a flavin reductase similar in biochemical properties to FRase I, the major flavin reductase in Vibrio fischeri, by a single amino acid substitution. J Bacteriol. 1996 Aug;178(15):4731-3.
9 Transformation of the anticancer drug doxorubicin in the human gut microbiome. ACS Infect Dis. 2018 Jan 12;4(1):68-76.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.