| General Information of Drug-Metabolizing Enzyme (DME ID: DME0148) |
| DME Name |
Pancreatic alpha-amylase (AMY2A), Homo sapiens
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DME Info
|
| UniProt ID |
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| EC Number |
EC: 3.2.1.1 (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.1
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Interactions between Xenobiotics and DME (XEOTIC)
|
| Health or Environmental Toxicant(s) |
|---|
| Acute Toxic Substance |
Click to Show/Hide the Full List of Xenobiotics: 1 Xenobiotics
|
| Cadmium |
Click to Show/Hide the Detail |
Inhibition |
| XEOTIC ID |
XEO01503
XEOTIC Info
|
Gene Form |
mRNA |
| Classification |
Acute Toxic Substance |
| DME Modulation |
Cadmium inhibits the expression of DME AMY2A |
[1] |
| Natural Product(s), Extract(s) or Medicine(s) |
|---|
| Plant Extract |
Click to Show/Hide the Full List of Xenobiotics: 1 Xenobiotics
|
| Plant extracts |
Click to Show/Hide the Detail |
Induction |
| XEOTIC ID |
XEO01574
XEOTIC Info
|
Gene Form |
mRNA |
| Classification |
Plant Extract |
| DME Modulation |
Plant extracts up-regulates the expression of DME AMY2A |
[2] |
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| References |
| 1 |
Using expression profiling to understand the effects of chronic cadmium exposure on MCF-7 breast cancer cells. PLoS One. 2013 Dec 20;8(12):e84646.
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| 2 |
Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
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