Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01503)
Xenobiotics Name
Cadmium
Xenobiotics Type
Health or Environmental Toxicant(s)
Classification
Acute Toxic Substance
Structure
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3D MOL 2D MOL
PubChem CID
23973
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Alcohol dehydrogenase class-III (ADH5) DME Info Homo sapiens [1]
Alcohol dehydrogenase class-V (ADH6) DME Info Homo sapiens [2]
Aldo-keto reductase 1B1 (AKR1B1) DME Info Homo sapiens [2]
Porphobilinogen synthase (ALAD) DME Info Homo sapiens [3]
Aldehyde dehydrogenase 1 (ALDH1) DME Info Homo sapiens [4]
Alkaline phosphatase (ALPL) DME Info Homo sapiens [5]
Pancreatic alpha-amylase (AMY2A) DME Info Homo sapiens [6]
Catalase (CAT) DME Info Homo sapiens [7]
Choline O-acetyltransferase (CHAT) DME Info Homo sapiens [6]
Aromatase (CYP19A1) DME Info Homo sapiens [6]
Vitamin D(3) 24-hydroxylase (CYP24A1) DME Info Homo sapiens [6]
Thymidylate kinase (DTYMK) DME Info Homo sapiens [8]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info Homo sapiens [9], [10]
NADH-ubiquinone oxidoreductase 20 kDa (NDUFS7) DME Info Homo sapiens [6]
Propionyl-CoA carboxylase beta (PCCB) DME Info Homo sapiens [1]
Superoxide dismutase 1 (SOD1) DME Info Homo sapiens [11]
DME(s) Induced by This Xenobiotics
Small intestine reductase (AKR1B10) DME Info Homo sapiens [12], [8]
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [12]
Aldo-keto reductase 1C2 (AKR1C2) DME Info Homo sapiens [12], [8]
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [8]
Aldo-keto reductase 1D1 (AKR1D1) DME Info Homo sapiens [8]
Butyrylcholine esterase (BCHE) DME Info Homo sapiens [8]
Cytidine aminohydrolase (CDA) DME Info Homo sapiens [8]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [13]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [14]
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [8]
Leukotriene B4 omega-hydroxylase (CYP4F3) DME Info Homo sapiens [8]
Glutamine synthetase (GLUL) DME Info Homo sapiens [6]
Glutathione reductase (GSR) DME Info Homo sapiens [7]
Glutathione S-transferase omega-1 (GSTO1) DME Info Homo sapiens [1]
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [15]
N-acetyl-beta-glucosaminidase beta (HEXB) DME Info Homo sapiens [6]
Iduronate 2-sulfatase (IDS) DME Info Homo sapiens [1]
Monoamine oxidase type B (MAO-B) DME Info Homo sapiens [1]
Methionine-tRNA ligase mitochondrial (MARS2) DME Info Homo sapiens [6]
Metallothionein-1A (MT1A) DME Info Homo sapiens [16]
Metallothionein-2A (MT2A) DME Info Homo sapiens [16]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [17]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [12]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [18]
Putrescine acetyltransferase (SSAT1) DME Info Homo sapiens [12]
Steroid 5-alpha-reductase 1 (SRD5A1) DME Info Homo sapiens [6]
Steroid 5-alpha-reductase 2 (SRD5A2) DME Info Homo sapiens [8]
Sulfotransferase 2B1 (SULT2B1) DME Info Homo sapiens [8]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [19]
Thymidylate synthase (TYMS) DME Info Homo sapiens [20]
Uridine phosphorylase 1 (UPP1) DME Info Homo sapiens [12]
References
1 Short and long term gene expression variation and networking in human proximal tubule cells when exposed to cadmium. BMC Med Genomics. 2013;6 Suppl 1:S2.
2 Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
3 Comparative inhibition of enzymes of human erythrocytes and plasma in vitro by agricultural chemicals. Arch Environ Contam Toxicol. 1996 Jul;31(1):107-14.
4 Differential DNA methylation profile of key genes in malignant prostate epithelial cells transformed by inorganic arsenic or cadmium. Toxicol Appl Pharmacol. 2015 Aug 1;286(3):159-67.
5 Effects of sub-toxic Cadmium concentrations on bone gene expression program: results of an in vitro study. Toxicol In Vitro. 2010 Sep;24(6):1670-80.
6 Using expression profiling to understand the effects of chronic cadmium exposure on MCF-7 breast cancer cells. PLoS One. 2013 Dec 20;8(12):e84646.
7 Oxidative stress and DNA damage induced by cadmium in the human keratinocyte HaCaT cell line: role of glutathione in the resistance to cadmium. Toxicology. 2008 Jan 14;243(1-2):193-206.
8 Microarray analysis of gene expression patterns in human proximal tubule cells over a short and long time course of cadmium exposure. J Toxicol Environ Health A. 2011;74(1):24-42.
9 The ERK1/2 signaling pathway regulates 11beta-hydroxysteroid dehydrogenase type 2 expression in human trophoblast cells through a transcriptional mechanism. Biol Reprod. 2013 Oct 17;89(4):92.
10 Cadmium reduces 11 beta-hydroxysteroid dehydrogenase type 2 activity and expression in human placental trophoblast cells. Am J Physiol Endocrinol Metab. 2006 Jan;290(1):E135-E142.
11 Plasma lipid peroxidation and erythrocyte antioxidant enzymes status in workers exposed to cadmium. Toxicol Ind Health. 2006 Sep;22(8):329-35.
12 Identification and dissection of the Nrf2 mediated oxidative stress pathway in human renal proximal tubule toxicity. Toxicol In Vitro. 2011 Apr;25(3):613-22.
13 Effects of arsenic, cadmium, chromium, and lead on gene expression regulated by a battery of 13 different promoters in recombinant HepG2 cells. Toxicol Appl Pharmacol. 2000 Oct 15;168(2):79-90.
14 Relationships between non-occupational cadmium exposure and expression of nine cytochrome P450 forms in human liver and kidney cortex samples. Biochem Pharmacol. 2001 Sep 15;62(6):713-21.
15 Whole genome analysis and microRNAs regulation in HepG2 cells exposed to cadmium. ALTEX. 2012;29(2):173-82.
16 Increased levels of metallothionein in placenta of smokers. Toxicology. 2005 Mar 1;208(1):133-9.
17 Cadmium induces transcription independently of intracellular calcium mobilization. PLoS One. 2011;6(6):e20542.
18 Cadmium induces carcinogenesis in BEAS-2B cells through ROS-dependent activation of PI3K/AKT/GSK-3beta/beta-catenin signaling. Toxicol Appl Pharmacol. 2012 Oct 15;264(2):153-60.
19 Gene expression analysis using DNA microarray in HK-2 human proximal tubular cells treated with cadmium. J Toxicol Sci. 2013;38(6):959-62.
20 Induction of mitogenic signalling in the 1LN prostate cell line on exposure to submicromolar concentrations of cadmium+. Cell Signal. 2003 Nov;15(11):1059-70.

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